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首页> 外文期刊>Infection and immunity >Heparin inhibits phagocytosis by polymorphonuclear leukocytes.
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Heparin inhibits phagocytosis by polymorphonuclear leukocytes.

机译：肝素抑制多形核白细胞的吞噬作用。

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摘要

Phagocytosis of unopsonized Salmonella typhimurium 395, MR-10, opsonized Salmonella typhimurium 395 MS, and Staphylococcus epidermidis by rabbit polymorphonuclear leukocytes was inhibited by heparin at concentrations as low as 0.5 U/ml. Inhibition was dose dependent and nearly complete at 20 U/ml. Provided that heparin concentrations did not exceed 100 U/ml, inhibition could be largely reversed by washing. Heparin also reversibly inhibited the adherence of polymorphonuclear leukocytes to glass. In contrast, hexose monophosphate shunt activity of polymorphonuclear leukocytes stimulated by noningested S. typhimurium MR-10 or Streptococcus pyogenes B14 was not inhibited by heparin at concentrations as high as 100 U/ml.
机译：肝素以低至0.5 U / ml的浓度抑制兔多形核白细胞对未调理的鼠伤寒沙门氏菌395，MR-10，调理的鼠伤寒沙门氏菌395 MS和表皮葡萄球菌的吞噬作用。抑制作用是剂量依赖性的，在20 U / ml时几乎完成。如果肝素浓度不超过100 U / ml，则抑制作用可通过洗涤大大逆转。肝素还可逆地抑制多形核白细胞对玻璃的粘附。相反，在高达100 U / ml的浓度下，肝素未抑制由非消化性鼠伤寒沙门氏菌MR-10或化脓性链球菌B14刺激的多形核白细胞的己糖单磷酸分流活性。

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