Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs.

E Yarkoni; H J Rapp

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Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs.

机译：通过主动特异性免疫疗法对豚鼠中已建立的真皮肿瘤移植物和淋巴结转移进行回归。

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Guinea pigs, each with an established, syngeneic dermal tumor (line-10) and microscopic lymph node metastasis, were treated by intradermal inoculation of living line-10 tumor cells admixed with emulsified heat-killed Mycobacterium bovis BCG cells. This treatment caused complete regression of established dermal tumors (about 10 mm in diameter) and prevented the growth of microscopic lymph node metastases in 25 of 39 treated animals (64%). All control animals treated by intradermal inoculation with heat-killed M. bovis BCG cells attached to oil droplets died with progressive dermal and lymphatic tumor growth.

机译：通过皮内接种与乳化的热灭活的牛分枝杆菌BCG细胞混合的10号活肿瘤细胞，对每只豚鼠均已建立的同系皮肤肿瘤（10号线）和微小淋巴结转移进行治疗。该治疗导致已建立的真皮肿瘤（直径约10 mm）完全消退，并阻止了39只经治疗的动物中的25只（64％）的微小淋巴结转移的生长。通过皮内接种附着有油滴的热灭活的牛分枝杆菌BCG细胞进行皮内接种治疗的所有对照动物均死于皮肤和淋巴瘤的生长。

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《Infection and immunity》 |1981年第1期|共3页
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E Yarkoni; H J Rapp;
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1. Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs. [J] . E Yarkoni, H J Rapp Infection and immunity . 1981,第1期

机译：通过主动特异性免疫疗法对豚鼠中已建立的真皮肿瘤移植物和淋巴结转移进行回归。
2. Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases. [J] . Karamitopoulou E, Zlobec I, Koumarianou A, Cancer: A Journal of the American Cancer Society . 2010,第19期

机译：在经过辅助治疗的III期大肠癌患者的淋巴结转移中p16的表达确定了预后不良的亚组：对匹配的原发肿瘤和淋巴结转移中生物标志物的回顾性分析。
3. Successful adoptive immunotherapy of murine poorly immunogenic tumor with specific effector cells generated from gene-modified tumor-primed lymph node cells. [J] . Tanaka H, Yoshizawa H, Yamaguchi Y, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第6期

机译：用基因修饰的肿瘤引发的淋巴结细胞产生的特异性效应细胞成功成功地对小鼠免疫原性差的肿瘤进行过继免疫治疗。
4. Polymeric nanoparticles improve antibody delivery to tumors and tumor draining lymph nodes to enhance cancer immunotherapy via checkpoint inhibition [C] . David M. Francis, Alex Schudel, Nathan A. Rohner, Society for Biomaterials annual meeting and exposition . 2019

机译：聚合纳米颗粒改善了抗体向肿瘤和引流淋巴结的递送，从而通过检查点抑制增强了癌症免疫疗法
5. Evaluation of pathologic parameters and published nomograms in predicting non-sentinel lymph node metastases in female breast cancer patients with positive sentinel lymph nodes. [D] . Murch, Lisa Elaine. 2007

机译：在前哨淋巴结阳性的女性乳腺癌患者中预测非前哨淋巴结转移的病理参数和公布的列线图评估。
6. Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs. [O] . E Yarkoni, H J Rapp 1981

机译：通过主动特异性免疫疗法对豚鼠中已建立的真皮肿瘤移植物和淋巴结转移进行回归。
7. Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs [O] . E Yarkoni, H J Rapp 1981

机译：在豚鼠中的已建立的皮肤肿瘤移植和淋巴结转移的活性特异性免疫疗法回归
8. Results of a Local Lymph Node Assay (LLNA) and Delayed Dermal Sensitization Study in the Guinea Pig (Buehler test) with 2-hexyl- Decanoic Acid. [R] . 2010

机译：用2-己基 - 癸酸在豚鼠（Buehler试验）中进行局部淋巴结测定（LLNa）和延迟皮肤致敏试验的结果。

Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs.

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