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首页> 外文期刊>Infection and immunity >Restricted replication of herpes simplex virus in spinal ganglia of resistant mice is accompanied by an early infiltration of immunoglobulin G-bearing cells.
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Restricted replication of herpes simplex virus in spinal ganglia of resistant mice is accompanied by an early infiltration of immunoglobulin G-bearing cells.

机译：单纯性疱疹病毒在耐药小鼠的脊髓神经节中复制受限，并伴有早期免疫球蛋白G浸润细胞。

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摘要

In an attempt to define the nature of the difference in the susceptibility of C57BL/6 (resistant) and A/J (susceptible) mice to herpes simplex virus type 1, we initiated a study of virus progression through the nervous system. After inoculation of virus in a rear footpad, C57BL/6 mice were found to be more than 500-fold more resistant, but resistance did not extend to pseudorabies virus. In additional investigations, it was found that the virus was selectively restricted at the level of spinal ganglia in C57BL/6 mice. No intrinsic difference in the ability of this tissue from either mouse strain to replicate virus was found. However, by 4 days after infection, morphological investigations indicated that a mononuclear cell infiltrate was present surrounding infected neurons and satellite cells both earlier and in greater numbers in the ganglia of C57BL/6 mice. Immunohistochemical methods showed that most of these cells did not express Thy 1.2 antigen, but the vast majority bore immunoglobulin G. The mechanism by which these infiltrating cells could restrict virus spread is discussed.
机译：为了定义C57BL / 6（抗性）和A / J（易感）小鼠对单纯疱疹病毒1型的敏感性差异的性质，我们启动了病毒在神经系统中传播的研究。在后脚垫中接种病毒后，发现C57BL / 6小鼠的抵抗力高500倍以上，但抵抗力并未扩展到伪狂犬病病毒。在其他研究中，发现该病毒在C57BL / 6小鼠的脊髓神经节水平受到选择性限制。在任一小鼠品系中该组织复制病毒的能力均未发现内在差异。但是，到感染后第4天，形态学研究表明C57BL / 6小鼠神经节中较早且以更大数量存在被感染神经元和卫星细胞周围的单核细胞浸润。免疫组织化学方法显示，这些细胞大多数不表达Thy 1.2抗原，但绝大多数都带有免疫球蛋白G。讨论了这些浸润细胞限制病毒传播的机制。

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