Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

R G Rank; A L Barron

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Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

机译：雌二醇对衣原体眼和生殖器感染中生殖器粘膜抗体反应的特异性作用。

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Estradiol treatment of female guinea pigs was found to alter the course of genital, but not ocular, infection with the chlamydial agent of guinea pig inclusion conjunctivitis. Immunoglobulin G (IgG) and IgA responses in genital secretions of genitally infected animals were delayed by estradiol treatment, but neither response in the eye resulting from either ocular or genital infection was affected. However, the appearance of IgG in the genital tract after ocular infection was markedly inhibited in estradiol-treated guinea pigs.

机译：发现雌二醇对雌性豚鼠的治疗改变了豚鼠包涵体结膜炎的衣原体感染的生殖器进程，但不会改变其感染过程。雌二醇治疗可延缓生殖器感染动物生殖器分泌物中的免疫球蛋白G（IgG）和IgA反应，但无论是眼部感染还是生殖器感染都不会影响眼睛的反应。然而，在经雌二醇处理的豚鼠中，眼部感染后在生殖道中IgG的出现被显着抑制。

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《Infection and immunity》 |1987年第9期|共3页
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R G Rank; A L Barron;
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中图分类医学免疫学;
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1. Protective or pathogenic immune response to genital chlamydial infection in women--a possible role of cytokine secretion profile of cervical mucosal cells. [J] . Agrawal T, Gupta R, Dutta R, Clinical immunology: The official journal of the Clinical Immunology Society . 2009,第3期

机译：对女性生殖道衣原体感染的保护性或病原性免疫反应-宫颈粘膜细胞的细胞因子分泌谱可能发挥的作用。
2. Protective immunity against mouse upper genital tract pathology correlates with high IFN gamma but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway. [J] . Lu C. X., Zeng H., Li Z. H., Vaccine . 2012,第2期

机译：针对小鼠上生殖道病理的保护性免疫与高IFNγ但低IL-17 T细胞和由在气道中复制衣原体生物体诱导的抗分泌蛋白抗体反应有关。
3. Estradiol limits viral replication following intravaginal immunization leading to diminished mucosal IgG response and non-sterile protection against genital herpes challenge. [J] . Gillgrass A, Chege D, Bhavanam S, AJRI: American Journal of Reproductive Immunology . 2010,第4期

机译：雌二醇限制了阴道内免疫后的病毒复制，导致粘膜IgG应答减少和针对生殖器疱疹攻击的非无菌保护。
4. The biodegradable polymeric PLA-PEG nanoparticles is an efficient delivery system for a chlamydial M278 mucosal nanovaccine that provides protective systemic and mucosal antibody responses in mice [C] . Richa Verma, Rajnish Sahu, Saurabh Dixit, Annual techconnect world innovation conference expo;Defense techconnect DTS conference;Annual nanotech conference expo;SBIR/STTR innovation conference . 2018

机译：可生物降解的聚合物PLA-PEG纳米颗粒是衣原体M278粘膜纳米疫苗的有效递送系统，可在小鼠中提供保护性全身和粘膜抗体反应
5. Design of amino acid prodrugs of acyclovir for improved bioavailability and therapeutic activity: Utility in treating ocular, oral and genital herpes infections. [D] . Katragadda, Suresh. 2007

机译：设计用于提高生物利用度和治疗活性的阿昔洛韦的氨基酸前药：用于治疗眼，口腔和生殖器疱疹感染。
6. Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections. [O] . R G Rank, A L Barron 1987

机译：雌二醇对衣原体眼和生殖器感染中生殖器粘膜抗体反应的特异性作用。
7. Mucosal and systemic immune responses to plasmid protein pgp3 in patients with genital and ocular Chlamydia trachomatis infection [O] . Ghaem-Maghami, S, Ratti, G, Ghaem-Maghami, M, 2003

机译：生殖器和眼沙眼衣原体感染患者对质粒蛋白pgp3的粘膜和全身免疫反应
8. Use of a Guinea Pig-Specific Transcriptome Array for Evaluation of Protective Immunity against Genital Chlamydial Infection following Intranasal Vaccination in Guinea Pigs. [R] . Wali, S., Gupta, R., Veselenak, R. L., 2014

机译：使用豚鼠特异性转录组阵列评估豚鼠鼻内接种后生殖器衣原体感染的保护性免疫。

Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

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