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首页> 外文期刊>Infection and immunity >Characterization of cyclophosphamide-rat model of cryptosporidiosis.
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Characterization of cyclophosphamide-rat model of cryptosporidiosis.

机译：隐孢子虫病的环磷酰胺大鼠模型的表征。

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A cyclophosphamide-treated-rat model for cryptosporidiosis is described. The optimal conditions for inducing a cryptosporidial infection in rats were a 50 mg/kg dose of cyclophosphamide per day in the drinking water for a minimum of 14 days before inoculation with 10(4) or more infectious oocysts. Eighteen days after inoculation, 80% or more of the animals were infected. Cryptosporidia were attached to the terminal 24 cm of the small intestine, and the immunosuppressed animals remained infected as long as they received cyclophosphamide. However, the intestinal infection cleared within 7 to 10 days after cyclophosphamide was withdrawn. Oocysts continued to be detected in the feces for an additional 5 to 7 days after cryptosporidia were no longer visibly attached to the ideal enterocytes. This study characterized an animal model that can be used to investigate the pathogenesis of and evaluate therapeutic regimens for cryptosporidiosis in the immunocompromised host.
机译：描述了一种用于隐孢子虫病的环磷酰胺治疗的大鼠模型。诱导大鼠隐孢子虫感染的最佳条件是每天在饮用水中以50 mg / kg的剂量施用环磷酰胺，持续至少14天，然后再接种10（4）个或更多的感染性卵囊。接种18天后，感染了80％或更多的动物。隐孢子虫附着在小肠的末端24 cm处，只要免疫抑制的动物接受环磷酰胺，它们就仍然受到感染。但是，撤回环磷酰胺后7到10天内肠感染会清除。在隐孢子虫不再可见地附着于理想的肠上皮细胞后的另外5到7天，仍在粪便中检测到了卵囊。这项研究的特点是动物模型，可用于调查免疫受损宿主中隐孢子虫病的发病机理并评估治疗方案。

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