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首页> 外文期刊>Infection and immunity >Macrophage activation as an immune correlate to protective immunity against schistosomiasis in mice immunized with an irradiated, cryopreserved live vaccine.
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Macrophage activation as an immune correlate to protective immunity against schistosomiasis in mice immunized with an irradiated, cryopreserved live vaccine.

机译：巨噬细胞激活作为一种免疫反应，与用辐照，冷冻保存的活疫苗免疫的小鼠的血吸虫病的保护性免疫有关。

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摘要

Immune responses against Schistosoma mansoni were evaluated in C57BL/6 mice injected with one of two populations of irradiated schistosomules, the larval preparations differing only in the degree of freezing-induced damage sustained upon cryopreservation. Mice injected with larvae which successfully withstood cryopreservation showed a significant reduction in worm burden following cercarial challenge. No protection was achieved in mice which received larvae damaged by a suboptimal thawing rate. Parallel comparison of several humoral and cellular responses in mice which received either inoculum revealed that induction of activated macrophages and production of macrophage-activating lymphokine activity were the strongest correlates to development of protective immunity. Protected mice also showed marginal 30-min skin test reactivity and weak but transient 24-h delayed-type hypersensitivity to a soluble adult worm preparation. In contrast, indistinguishable levels of circulating antibodies to soluble and tegumental antigens developed in the two immunization groups, and antigen-stimulated lymphocyte blastogenic responses were strong and essentially equivalent in magnitude. These studies strongly suggested that in this new model for investigating anti-schistosome effector mechanisms, responses contributing to the development of activated macrophages may be essential for induction of protective immunity.
机译：在注射了两个辐射过的血吸虫群体之一的C57BL / 6小鼠中评估了对曼氏血吸虫的免疫反应，其幼虫制剂的不同之处仅在于冷冻保存后冷冻诱导的损伤程度。注射了能够成功抵抗冷冻保存的幼虫的小鼠，在小脑攻击后显示出蠕虫负担的显着降低。在解冻速率不理想的幼虫中，没有获得保护。对接受了两种接种物的小鼠的几种体液和细胞反应的平行比较显示，激活巨噬细胞的诱导和激活巨噬细胞的淋巴因子活性的产生与保护性免疫的发展最相关。受保护的小鼠还显示出对边缘30分钟的皮肤测试反应性以及对可溶性成虫的微弱但短暂的24小时延迟超敏反应。相反，在两个免疫组中，针对可溶性抗原和被膜抗原的循环抗体水平难以区分，并且抗原刺激的淋巴细胞成胚反应很强，并且在强度上基本相等。这些研究强烈建议，在这种研究抗血吸虫病效应子机制的新模型中，有助于活化巨噬细胞发育的应答可能对诱导保护性免疫至关重要。

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