...
首页> 外文期刊>Infection and immunity >Cytokines as adjuvants for vaccines: antigen-specific responses differ from polyclonal responses.
【24h】

Cytokines as adjuvants for vaccines: antigen-specific responses differ from polyclonal responses.

机译:细胞因子作为疫苗佐剂:抗原特异性反应不同于多克隆反应。

获取原文
           

摘要

The use of cytokines in the administration of vaccines has a unique value in obtaining the appropriate immune response and in ensuring a protective outcome. Earlier studies indicating that cytokines can influence the generation of a particular antibody isotype may represent an oversimplification of a more complex problem. Several studies discussed in this review show that the effect of a given cytokine on the immune response depends on whether one examines the antigen-specific response or the polyclonal response (i.e., total serum immunoglobulins). Further, a balanced regulation of immune responsiveness is important in maintaining homeostasis of the immune system. Consequently, for any vaccine that uses cytokines to boost the response, due consideration must be given to these important variables.
机译:在接种疫苗中使用细胞因子在获得适当的免疫应答和确保保护效果方面具有独特的价值。较早的研究表明,细胞因子可以影响特定抗体同种型的产生,这可能代表了更为复杂的问题的过度简化。这篇综述中讨论的几项研究表明,给定细胞因子对免疫反应的影响取决于是否检查抗原特异性反应或多克隆反应(即总血清免疫球蛋白)。此外,免疫应答的平衡调节对于维持免疫系统的体内平衡很重要。因此,对于使用细胞因子来增强应答的任何疫苗,必须适当考虑这些重要变量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号