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首页> 外文期刊>Infection and immunity >Changes to the ocular biota with time in extended- and daily-wear disposable contact lens use.
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Changes to the ocular biota with time in extended- and daily-wear disposable contact lens use.

机译：在长期和日常佩戴的一次性隐形眼镜使用中，眼部生物随时间的变化。

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Gram-negative bacteria may play a role in the etiology of certain soft contact lens (SCL)-related diseases. Contact lens (CL) wear may modify the normal ocular biota, providing a more favorable environment for potential pathogens. This study reports temporal changes in ocular biota in daily-wear (DW) and extended-wear (EW) disposable SCL use in experienced and neophyte wearers. Lid margin and bulbar conjunctival biota were sampled prior to CL fitting in 26 previous DW SCL users, 18 previous EW SCL users, and 26 neophytes. Wearers were fitted with an etafilcon A CL in one eye and a polymacon CL in the fellow eye. Lenses were worn on a daily basis by the 26 previous DW SCL wearers and on an EW basis by the remaining 44 subjects. The ocular biota was further sampled after 1, 3, 6, 9, and 12 months of wear. The ocular biota consisted of coagulase-negative staphylococci, Corynebacterium spp., Micrococcus spp., and Propionibacterium spp. Potential pathogens were rarely isolated at baseline. No significant trend of increasing ocular colonization was shown for extended CL wear. Lid and conjunctival colonization increased with DW SCL use (P < 0.001), although this increase occurred for nonpathogenic species only. Fewer potential pathogens were isolated from DW SCL than from EW SCL users (P < 0.05). The lid margin consistently showed greater colonization than the conjunctiva and may be a source of potential pathogens during CL wear. Hydrogel CL wear appears to modify the ocular biota. An increased number of commensal organisms were present in DW SCL use. EW SCL use altered the spectrum of organisms isolated. These alterations may suppress the normal ocular defense mechanisms and may be relevant in the pathogenesis of CL-related disease.
机译：革兰氏阴性细菌可能在某些与软性接触镜（SCL）相关的疾病的病因中起作用。隐形眼镜（CL）的佩戴可能会改变正常的眼部生物区，为潜在的病原体提供更有利的环境。这项研究报告了有经验的和初生的佩戴者在日常佩戴（DW）和长期佩戴（EW）一次性SCL中眼部生物群的时间变化。在进行CL拟合之前，对26位以前的DW SCL用户，18位以前的EW SCL用户和26位新植物进行CL拟合之前，对盖缘和球结膜生物群进行了采样。配戴者的一只眼睛装有etafilcon A CL，另一只眼睛装有polymacon CL。以前有26位DW SCL佩戴者每天佩戴镜片，其余44位受试者每天佩戴镜片。在1、3、6、9和12个月的佩戴后，进一步对眼部生物群进行采样。眼部生物群由凝固酶阴性葡萄球菌，棒杆菌属，微球菌属和丙酸杆菌属组成。在基线时很少分离出潜在的病原体。对于长时间的CL佩戴，没有显示出明显的眼部集落趋势。随DW SCL的使用，盖和结膜定植增加（P <0.001），尽管这种增加仅发生在非致病菌种上。从DW SCL中分离出的潜在病原体少于从EW SCL用户中分离出的潜在病原体（P <0.05）。眼睑边缘始终显示出比结膜更大的定殖，并且可能是CL佩戴期间潜在病原体的来源。水凝胶CL的磨损似乎会改变眼部生物群。 DW SCL使用中的共生生物数量增加。 EW SCL的使用改变了所分离生物的范围。这些改变可能会抑制正常的眼部防御机制，并且可能与CL相关疾病的发病机制有关。

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