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首页> 外文期刊>Infection and immunity >Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats.
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Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats.

机译:眼镜蛇毒因子的逆补充作用可抑制大鼠耶尔森氏菌引起的关节炎。

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Lewis rats experimentally infected with Yersinia enterocolitica O8 develop Yersinia-induced arthritis (YIA), which resembles very much reactive arthritis in humans. To investigate the involvement of serum complement in induction and maintenance of YIA, we decomplementated Yersinia-infected Lewis rats by treatment with cobra venom factor starting on day 7 after infection (prearthritic state). Reduction of serum complement activity in vivo by cobra venom factor treatment coincided with suppression of YIA clinically and histomorphologically.
机译:实验性感染小肠结肠炎耶尔森氏菌O8的Lewis大鼠会患上耶尔森氏菌引起的关节炎(YIA),与人类的反应性关节炎非常相似。为了研究血清补体在YIA的诱导和维持中的作用,我们从感染后第7天开始(眼镜蛇状态),通过眼镜蛇毒因子的治疗使被耶尔森氏菌感染的Lewis大鼠失代偿。在临床和组织形态学上,通过眼镜蛇毒因子治疗降低体内血清补体活性与抑制YIA相吻合。

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