Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.

U Sibelius; F Rose; T Chakraborty; A Darji; J Wehland; S Weiss; W Seeger; F Grimminger

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Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.

机译：李斯特菌溶血素是人内皮细胞中磷脂酰肌醇反应和脂质介体生成的有效诱导剂。

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The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is linked to production of LLO.

机译：研究了人脐静脉内皮细胞中单核细胞增生李斯特菌李斯特菌溶血素O（LLO）分泌对磷酸肌醇代谢和介质（血小板激活因子和前列腺素I2）生成的影响。野生型单核细胞增生李斯特菌，纯化的LLO和工程改造为分泌LLO的无毒李斯特菌均引起强烈反应，而LLO产生缺陷的突变菌株无效。因此，利斯特氏菌刺激人脐静脉内皮细胞与LLO的产生有关。

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《Infection and immunity》 |1996年第2期|共3页
作者
U Sibelius; F Rose; T Chakraborty; A Darji; J Wehland; S Weiss; W Seeger; F Grimminger;
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中图分类医学免疫学;
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1. Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells. [J] . U Sibelius, F Rose, T Chakraborty, Infection and immunity . 1996,第2期

机译：李斯特菌溶血素是人内皮细胞中磷脂酰肌醇反应和脂质介体生成的有效诱导剂。
2. Effect of SR121566A, a potent GP IIb-IIIa antagonist, on the HIT serum/heparin-induced platelet mediated activation of human endothelial cells. [J] . Herbert JM, Savi P, Jeske WP, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 1998,第2期

机译：强大的GP IIb-IIIa拮抗剂SR121566A对HIT血清/肝素诱导的血小板介导的人内皮细胞活化的影响。
3. Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cells. [J] . Matsunaga N, Shimazawa M, Otsubo K, Journal of pharmacological sciences. . 2008,第1期

机译：磷脂酰肌醇抑制血管内皮生长因子-A诱导的人脐静脉内皮细胞迁移。
4. CpG ADSORBED ONTO AG-LOADED PLGA MICROPARTICLES INDUCED A POTENT ACTIVATION OF SPECIFIC CD8 T CELLS. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：吸附在加载Ag加载的PLGA微粒上的CPG诱导特异性CD8 T细胞的有效活化。
5. Mechanical cyclic strain induces ceramide generation in endothelial cells. [D] . Hunter, Oriana C. 2009

机译：机械循环应变诱导内皮细胞中神经酰胺的产生。
6. Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells. [O] . U Sibelius, F Rose, T Chakraborty, 1996

机译：李斯特菌溶血素是人内皮细胞中磷脂酰肌醇反应和脂质介体生成的有效诱导剂。
7. Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells [O] . U Sibelius, F Rose, T Chakraborty, 1996

机译：Listeriolysin是人类内皮细胞中磷脂酰肌醇反应和脂质介质产生的有效诱导剂

Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.

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