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首页> 外文期刊>Infection and immunity >Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens.
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Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens.

机译：免疫球蛋白A在小鼠血吸虫病中的反应：鸡蛋抗原的刺激作用。

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摘要

The immunoglobulin G (IgG) and IgA antibody responses to different Schistosoma mansoni antigens have been determined in chronically infected mice as well as in unisexually infected animals. With a panel of enzyme-linked immunosorbent assays (ELISAs), soluble antigens from furcocercariae, adult worms, and eggs were probed with sera collected at 3-week intervals. Bisexually infected animals developed significant IgG and IgA antibody responses to the antigens tested, which increased after egg deposition. In unisexual infections no significant differences were recorded in the IgG antibody profile for furocercaria and adult worm antigens, whereas the IgA antibody response was impaired. Both the IgA and IgG antibody responses toward egg antigens were reduced compared with those in a bisexual infection. Furthermore, a specific mucosal IgA antibody response was observed only in the bisexually infected animals. Histological analysis performed on bisexually infected mice led to the observation of eggs and granulomatous lesions within the Peyer's patch follicles, which are essential sites for the induction of mucosal immunity in the intestine. These data suggest a relationship between egg deposition and the induction of the IgA antibody response toward schistosomes.
机译：已经在慢性感染的小鼠以及单性感染的动物中确定了针对不同曼氏血吸虫抗原的免疫球蛋白G（IgG）和IgA抗体应答。使用一组酶联免疫吸附测定（ELISA），以3周为间隔的血清探测毛fur，成虫和卵中的可溶性抗原。被双性恋感染的动物对测试的抗原产生了显着的IgG和IgA抗体反应，这种反应在产卵后增加。在单性感染中，潮虫和成年蠕虫抗原的IgG抗体谱没有显着差异，而IgA抗体应答受到损害。与双性恋感染者相比，针对蛋抗原的IgA和IgG抗体反应均降低。此外，仅在双性恋感染的动物中观察到特异性粘膜IgA抗体应答。对双性恋感染小鼠进行的组织学分析导致​​观察到了Peyer斑卵泡中的卵和肉芽肿性病变，这是在肠道中诱导粘膜免疫的重要部位。这些数据表明卵沉积和诱导对血吸虫的IgA抗体应答之间的关系。

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