...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Early Cytokine and Chemokine Gene Expression duringPseudomonas aeruginosa Corneal Infection in Mice
【24h】

Early Cytokine and Chemokine Gene Expression duringPseudomonas aeruginosa Corneal Infection in Mice

机译：铜绿假单胞菌角膜感染小鼠早期细胞因子和趋化因子基因的表达

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Using a multiprobe RNase protection assay, we examined cytokine and chemokine mRNAs that were expressed after corneal infection withPseudomonas aeruginosa in mice. Cytokines that were upregulated included interleukin-1α (IL-1α) and -1β, IL-1 receptor antagonist, IL-6, IL-11, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, stem cell factor, lymphotoxin β, transforming growth factor β1, and tumor necrosis factor alpha. Chemokine transcripts that were upregulated included Eotaxin; gamma-interferon-inducible protein 10; monocyte chemoattractant protein 1; macrophage inflammatory proteins 1α, 1β, and 2; and RANTES. Peak expression of these cytokines and chemokines was observed between 1 and 3 days after infection. These responses returned to or approached baseline preinfection levels by 7 days after ocular challenge. Identification of the various cytokines and chemokines upregulated during corneal infection provides important information relevant to unraveling the pathogenesis induced by this bacterium and provides hope that specific molecules can be targeted for therapy.
机译：使用多探针RNase保护试验，我们检测了小鼠铜绿假单胞菌感染角膜后表达的细胞因子和趋化因子mRNA。上调的细胞因子包括白介素-1α（IL-1α）和-1β，IL-1受体拮抗剂，IL-6，IL-11，粒细胞集落刺激因子，粒细胞-巨噬细胞集落刺激因子，巨噬细胞集落刺激因子，干细胞因子，淋巴毒素β，转化生长因子β1和肿瘤坏死因子α。上调的趋化因子转录本包括嗜酸细胞活化趋化因子; γ-干扰素诱导蛋白10;单核细胞趋化蛋白1;巨噬细胞炎性蛋白1α，1β和2;和RANTES。在感染后1至3天观察到这些细胞因子和趋化因子的峰值表达。在眼刺激后7天，这些反应恢复到或接近基线感染前水平。角膜感染过程中上调的各种细胞因子和趋化因子的鉴定提供了与弄清该细菌诱导的发病机理有关的重要信息，并为特定分子可以靶向治疗提供了希望。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号