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首页> 外文期刊>Infection and immunity >Infection-Associated Decline of Cape Buffalo Blood Catalase Augments Serum Trypanocidal Activity
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Infection-Associated Decline of Cape Buffalo Blood Catalase Augments Serum Trypanocidal Activity

机译：布法罗角血过氧化氢酶的感染相关下降增强了血清锥虫活性

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Clearance of trypanosomes from the blood of infected Cape buffalo was associated with the development of two responses: (i) complement-dependent and clone-specific lytic activity and (ii) complement-independent trypanocidal activity that was not restricted by trypanosome clone or species. This latter activity was mediated by H2O2 and required the presence of xanthine oxidase in serum but not the addition of purine substrates. Expression of the xanthine oxidase-dependent trypanocidal activity in Cape buffalo serum was coincident with, and required, a decline in its H2O2catabolic activity. The H2O2 catabolic activity of Cape buffalo serum was due solely to catalase and declined by eightfold around the time that trypanosomes were cleared from the blood, accompanied by a fivefold drop in erythrocyte-associated catalase activity. The Cape buffalo did not develop subsequent parasitemic waves. Clearance of parasitemia in similarly infected cattle was also associated with development of trypanosome clone-specific lytic activity, but not with the acquisition of H2O2-dependent trypanocidal activity in serum, and the cattle supported recurring parasitemia. The lack of trypanocidal activity in pre- and postinfection cattle sera was due to their low content of xanthine oxidase and sustained catalase activity. These data strongly suggest that an infection-induced serum oxidative response, the efficacy of which is amplified by a decline in blood catalase, contributes to suppression of recurring parasitemia in Cape buffalo.
机译：从感染的Cape Buffalo血液中清除锥虫体与以下两种反应的发生有关：（i）依赖补体的和克隆特异性的裂解活性，以及​​（ii）不受锥虫体的克隆或物种限制的不依赖补体的锥虫活性。后者的活性是由H 2 O 2 介导的，需要血清中存在黄嘌呤氧化酶，而不需要添加嘌呤底物。黄嘌呤氧化酶依赖性锥虫杀虫活性在水牛角血清中的表达与H 2 O 2 分解代谢活性的降低是一致的，并且是必需的。 Cape Buffalo血清的H 2 O 2 分解代谢活性完全是由过氧化氢酶引起的，并且在从血液中清除锥虫的时间下降了八倍，伴随着五倍的下降在红细胞相关的过氧化氢酶活性。 Cape Buffalo没有随后的寄生虫波。在类似感染的牛中清除寄生虫病也与锥虫体克隆特异性裂解活性的发展有关，但与血清中H 2 O 2 依赖性锥虫杀灭活性的获得无关，并且牛支持复发性寄生虫病。感染前和感染后牛血清缺乏锥虫活性是由于其黄嘌呤氧化酶含量低和持续的过氧化氢酶活性。这些数据有力地表明，感染引起的血清氧化反应（其功效因血液过氧化氢酶的减少而增强）有助于抑制水牛角的复发性寄生虫病。

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