Binding and Activation of Human Plasminogen byMycobacterium tuberculosis

Verónica Monroy; Angelica Amador; Blanca Ruiz; Patricia Espinoza-Cueto; Wendy Xolalpa; Raul Mancilla; Clara Espitia

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Binding and Activation of Human Plasminogen byMycobacterium tuberculosis

机译：结核分枝杆菌对人纤溶酶原的结合和激活

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The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, α2-antiplasmin, was also demonstrated.

机译：本文报道了结核分枝杆菌与纤溶酶原系统相互作用的第一个证据。通过FACScan分析和亲和印迹，证明了纤溶酶原与结核分枝杆菌的赖氨酸依赖性结合。结合分子是存在于细胞壁和可溶性蛋白质提取物中的30-，60-和66-kDa蛋白质。还证明了纤溶酶原的活化仅在纤维蛋白存在下发生，并且不受宿主丝氨酸蛋白酶抑制剂α2-抗纤溶酶的抑制。

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《Infection and immunity》 |2000年第7期|共4页
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Verónica Monroy; Angelica Amador; Blanca Ruiz; Patricia Espinoza-Cueto; Wendy Xolalpa; Raul Mancilla; Clara Espitia;
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中图分类医学免疫学;
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机译：组织型纤溶酶原激活剂与葡萄糖调节蛋白质78（GRP78）的结合调节纤溶酶原激活并促进体外人神经母细胞瘤细胞增殖
2. Binding of human urokinase type plasminogen activator and plasminogen to Borrelia species. [J] . Klempner MS, Noring R, Epstein MP, The Journal of Infectious Diseases . 1996,第1期

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3. A comparative study of amyloid-beta (1-42) as a cofactor for plasminogen activation by vampire bat plasminogen activator and recombinant human tissue-type plasminogen activator. [J] . Kruithof EK, Schleuning WD Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2004,第3期

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5. A structure-function analysis of the lysine-binding kringle 2 domains of human tissue-type plasminogen activator and human plasminogen by strategic mutagenesis. [D] . Nilsen, Stephanie Lynn. 1999

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机译：肝素结合表皮生长因子样生长因子：p91激活纤溶酶原激活物/纤溶酶原激活物抑制剂的诱导和人微血管内皮细胞的管状形态发生。
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机译：用偶联杆菌的人嗜中性粒细胞的激活涉及磷脂酶Cγ2，SHC衔接子蛋白和P38丝裂剂活化蛋白激酶

Binding and Activation of Human Plasminogen byMycobacterium tuberculosis

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