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首页> 外文期刊>Infection and immunity >HLA-restricted T lymphocyte-mediated cytotoxicity against herpes simplex virus-infected cells in humans.
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HLA-restricted T lymphocyte-mediated cytotoxicity against herpes simplex virus-infected cells in humans.

机译：HLA限制T淋巴细胞介导的对人单纯疱疹病毒感染的细胞的细胞毒性。

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摘要

Cytotoxic T lymphocytes (CTL) against herpes simplex virus (HSV) were induced in vitro from human peripheral blood lymphocytes by stimulation with HSV antigen. CTL generated by HSV type 1 (HSV-1) antigen stimulation killed not only HSV-1-infected target cells but also HSV type 2 (HSV-2)-infected target cells, though at a lower level. This evidence suggests that CTL against HSV recognize the HSV type-specific and type-common determinants on HSV-infected target cells. These CTL were generated from high responders against HSV-1 antigen as measured by antigen-specific T lymphocyte proliferation in vitro, but not to such an efficient degree from low responders. The cytotoxic activities of CTL against the allogeneic HSV-infected target cells were high when at least one of the HLA-A or -B antigens was shared. However, the HLA-A and -B nonidentical target cells were not killed effectively. The data presented here suggest the possibility of HLA restriction of HSV-specific CTL in humans.
机译：通过单纯疱疹病毒抗原的刺激，从人外周血淋巴细胞体外诱导出针对单纯疱疹病毒（HSV）的细胞毒性T淋巴细胞（CTL）。通过HSV 1型（HSV-1）抗原刺激产生的CTL不仅杀死了感染HSV-1的靶细胞，而且杀死了感染HSV 2（HSV-2）的靶细胞，尽管其水平较低。该证据表明，针对HSV的CTL可以识别HSV感染的靶细胞上的HSV类型特异性决定簇和共同类型决定簇。这些CTL由对HSV-1抗原的高应答者产生，如通过体外抗原特异性T淋巴细胞的增殖所测量的，但对于低应答者而言却达不到如此有效的程度。当共享至少一种HLA-A或-B抗原时，CTL对同种异体HSV感染的靶细胞的细胞毒活性较高。但是，HLA-A和-B不同的靶细胞没有被有效杀死。此处提供的数据表明HLA限制了人类中HSV特异性CTL的可能性。

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