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首页> 外文期刊>Infection and immunity >Mouse monoclonal antibodies reactive with J5 lipopolysaccharide exhibit extensive serological cross-reactivity with a variety of gram-negative bacteria.
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Mouse monoclonal antibodies reactive with J5 lipopolysaccharide exhibit extensive serological cross-reactivity with a variety of gram-negative bacteria.

机译：与J5脂多糖反应的小鼠单克隆抗体与多种革兰氏阴性细菌表现出广泛的血清学交叉反应性。

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摘要

We describe two mouse monoclonal antibodies reactive with lipopolysaccharide derived from the J5 mutant of Escherichia coli O111:B4. These antibodies react with purified lipopolysaccharide derived from rough mutants of E. coli and Salmonella typhimurium and also with lipopolysaccharide associated with both smooth- and rough-phenotype, gram-negative bacteria. Both antibodies appear to bind determinants present in the lipopolysaccharide core region, and this reactivity is inhibited in the presence of polymyxin B. Although their patterns of reactivity differ, both antibodies exhibit extensive serological cross-reactivity with a variety of gram-negative bacteria. Reagents of this type should prove useful in animal models to delineate the requisite affinity, epitope specificity, immunoglobulin class, etc., needed for the prevention and treatment of gram-negative bacteremia.
机译：我们描述了两种小鼠单克隆抗体，它们与衍生自大肠杆菌O111：B4的J5突变体的脂多糖反应。这些抗体与衍生自大肠杆菌和鼠伤寒沙门氏菌的粗糙突变体的纯化脂多糖以及与光滑和粗糙表型革兰氏阴性细菌相关的脂多糖反应。两种抗体似乎都结合存在于脂多糖核心区域的决定簇，并且在多粘菌素B的存在下这种反应性受到抑制。尽管它们的反应模式不同，但是两种抗体均与多种革兰氏阴性细菌表现出广泛的血清学交叉反应性。这种类型的试剂应在动物模型中证明有用，以描述预防和治疗革兰氏阴性菌血症所需的必需亲和力，表位特异性，免疫球蛋白类别等。

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