Effect of theophylline on differentiation of Trypanosoma brucei.

S L Reed; A S Fierer; D R Goddard; M E Colmerauer; C E Davis

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Effect of theophylline on differentiation of Trypanosoma brucei.

机译：茶碱对布鲁氏锥虫分化的影响。

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Differentiation of Trypanosoma brucei in the mammal limits the degree of parasitemia and prepares the trypanosome for passage back into the tsetse fly. In an attempt to define the signals that control differentiation, we found that theophylline, in contrast to indomethacin, blocked differentiation, prolonged parasitemia, elevated prostaglandin and cyclic AMP concentrations of rat plasma, and depressed intratrypanosomal cyclic AMP. Relatively nontoxic drugs that alter differentiation are powerful tools for elucidating the events that control this important process.

机译：布氏锥虫在哺乳动物中的分化限制了寄生虫病的程度，并为锥虫做好了传回采采蝇的准备。在试图定义控制分化的信号时，我们发现与吲哚美辛相反，茶碱阻断了分化，延长了寄生虫血症，升高了前列腺素和大鼠血浆中的环状AMP浓度，并降低了胰内胰环内AMP。改变分化的相对无毒药物是阐明控制这一重要过程的事件的有力工具。

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《Infection and immunity》 |1985年第3期|共4页
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S L Reed; A S Fierer; D R Goddard; M E Colmerauer; C E Davis;
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中图分类医学免疫学;
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1. Effect of theophylline on differentiation of Trypanosoma brucei. [J] . S L Reed, A S Fierer, D R Goddard, Infection and immunity . 1985,第3期

机译：茶碱对布鲁氏锥虫分化的影响。
2. Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei. [J] . Herman M, Perez-Morga D, Schtickzelle N, Autophagy . 2008,第3期

机译：布氏锥虫生命周期分化过程中糖体的周转率。
3. Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei. [J] . Vassella E, Kramer R, Turner CM, Molecular Microbiology . 2001,第1期

机译：删除具有PX和FYVE相关域的新型蛋白激酶可提高布鲁氏锥虫的分化率。
4. Study of optically trapped living Trypanosoma cruzi/Trypanosoma rangeli - Rhodnius prolixus interactions by real time confocal images using CdSe quantum dots [C] . A. A. de Thomaz, D. B. Almeida, W. M. Faustino, Conference on optical trapping and optical micromanipulation . 2008

机译：光学捕获的活锥虫瘤rangeli / rangli - rangnius rangeli - rangnius rangeli使用Cdse量子点的实时共焦图像相互作用
5. Analysis of the Unique Binding Interactions within the 5S Ribonucleoprotein Particle (5S RNP) in Trypanosoma brucei. [D] . Kamina, Anyango D. 2018

机译：布氏锥虫5S核糖蛋白颗粒（5S RNP）中独特的结合相互作用的分析。
6. Effect of theophylline on differentiation of Trypanosoma brucei. [O] . S L Reed, A S Fierer, D R Goddard, 1985

机译：茶碱对布鲁氏锥虫分化的影响。
7. Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei. [O] . Elisha Mugo, Christine Clayton 2017

机译：RNa结合蛋白RBp10的表达促进布氏锥虫（Trypanosoma brucei）的血流形式分化状态。

Effect of theophylline on differentiation of Trypanosoma brucei.

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