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首页> 外文期刊>Infection and immunity >Susceptibility of germfree or antibiotic-treated adult mice to Cryptosporidium parvum.
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Susceptibility of germfree or antibiotic-treated adult mice to Cryptosporidium parvum.

机译：无菌或经抗生素处理的成年小鼠对小隐孢子虫的敏感性。

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Adult mice are more resistant than neonatal mice to intestinal colonization with the protozoan parasite Cryptosporidium parvum. Development of a mature intestinal flora may play a role in this resistance. We compared susceptibilities to colonization with C. parvum in adult conventional mice, adult germfree mice, and adult conventional mice treated with oral antibiotics to deplete the intestinal flora. Germfree mice of both CD1 and BALB/c strains were colonized at day 7 following inoculation with C. parvum oocysts isolated from the feces of an infected, diarrheic calf. Age-matched conventional mice of the same strains were comparatively resistant to colonization. Conventional mice treated with antibiotics remained resistant to colonization. These results suggest that the microflora in the intestine was not the sole determinant of resistance or susceptibility to colonization. The germfree adult mouse as an experimental model of cryptosporidiosis is discussed.
机译：成年小鼠对原生动物寄生虫小隐孢子虫的肠道定殖的抵抗力比新生小鼠高。成熟的肠道菌群的发育可能在这种抗性中起作用。我们比较了成年常规小鼠，成年无菌小鼠和用口服抗生素处理以减少肠道菌群的成年常规小鼠定殖小球藻的敏感性。接种从感染的腹泻小牛粪便中分离出的小隐孢子虫卵囊后，在第7天将CD1和BALB / c菌株的无胚小鼠定植。相同品系的年龄匹配的常规小鼠对定植具有相对抗性。用抗生素治疗的常规小鼠仍然对定植有抗性。这些结果表明，肠道菌群不是抵抗或对定植敏感性的唯一决定因素。讨论了成年无菌小鼠作为隐孢子虫病的实验模型。

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