An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.

B E Henricson; R Neta; S N Vogel

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An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.

机译：白介素-1受体拮抗剂阻断脂多糖诱导的集落刺激因子的产生和早期内毒素耐受性。

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In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena.

机译：在该报告中，发现对小鼠施用重组白介素-1受体拮抗剂蛋白可抑制集落刺激因子的诱导以及脂多糖诱导的早期内毒素耐受性。这些发现提供了直接的证据，表明白介素-1是这两种脂多糖诱导的现象的中间产物。

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《Infection and immunity》 |1991年第3期|共4页
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B E Henricson; R Neta; S N Vogel;
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中图分类医学免疫学;
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An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.

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