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首页> 外文期刊>Infection and immunity >Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans.
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Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans.

机译：人类口服霍乱疫苗接种后，外周血和唾液腺中产生抗体的细胞。

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We examined whether immunization with a newly developed oral cholera vaccine would elicit gut-derived antibody-producing cells in the blood and in distant mucosal tissues, such as the minor salivary glands, in 30 adult Swedish volunteers. The results of this study demonstrated that this vaccine indeed induced production of specific antibody-producing cells against the cholera toxin B subunit in both peripheral blood and salivary glands. The response in blood, which after primary and booster immunizations comprised both immunoglobulin A (IgA) and IgG antibody-forming cells, was highly transient and preceded the response in salivary glands; the latter response was restricted to the IgA isotype. The results provide further evidence of the existence of a common mucosal immune system in humans. Furthermore, these findings support previous observations that in animals, the cholera toxin B subunit may be a useful carrier protein for preparing enteric vaccines against pathogens encountered at intestinal and extraintestinal mucosal sites.
机译：我们研究了用新开发的口服霍乱疫苗免疫是否会在30名成年瑞典志愿者中引起血液和远处粘膜组织（例如唾液腺）中肠道来源的抗体产生细胞。这项研究的结果表明，该疫苗确实诱导了外周血和唾液腺中针对霍乱毒素B亚基的特异性抗体产生细胞的产生。血液中的反应在初次和加强免疫后均包含免疫球蛋白A（IgA）和IgG抗体形成细胞，其反应是高度瞬态的，并且在唾液腺中反应先于反应。后者的反应仅限于IgA同种型。结果提供了人类中常见的粘膜免疫系统存在的进一步证据。此外，这些发现支持了先前的观察结果，即在动物中，霍乱毒素B亚基可能是有用的载体蛋白，用于制备针对肠道和肠外黏膜部位的病原体的肠道疫苗。

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