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首页> 外文期刊>Infection and immunity >Recombinant derivatives of Pasteurella multocida toxin: candidates for a vaccine against progressive atrophic rhinitis.
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Recombinant derivatives of Pasteurella multocida toxin: candidates for a vaccine against progressive atrophic rhinitis.

机译:多杀性巴氏杆菌毒素的重组衍生物:抗进行性萎缩性鼻炎疫苗的候选药物。

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摘要

Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a lack of toxic activity. One such component was shown to induce efficient protection of vaccinated female mice and their offspring against challenge with purified P. multocida toxin.
机译:开发了用于预防猪萎缩性鼻炎的潜在疫苗成分。这是通过诱变编码多杀巴斯德氏菌毒素的基因的突变而实现的。四种纯化的毒素衍生物在氨基酸序列中缺乏不同且分布广泛的区域,其特征是缺乏毒性。一种这样的成分显示出可以有效地保护接种疫苗的雌性小鼠及其后代免受纯化的多杀疟原虫毒素的攻击。

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