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首页> 外文期刊>Infection and immunity >Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
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Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.

机译：利什曼原虫反应性CD4 +和CD8 + T细胞与人类皮肤利什曼病的治愈相关。

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Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.
机译：研究了十四名患有美国皮肤利什曼病的患者。进行了巴西利什曼原虫抗原体外诱导的淋巴细胞增殖反应的测定。培养5天后，收获巴西乳杆菌刺激的胚细胞T细胞用于CD4 +和CD8 +表型分析。比较治疗前和治疗结束时的结果，利什曼病患者显示培养物中CD8 + blast T细胞的百分比增加，而CD4 + blast T细胞的比例下降。治愈后，T细胞培养上清液中的γ干扰素水平有增加的趋势。这些结果表明，治愈后，利什曼原虫反应性CD8 + T细胞比例较高，而利什曼原虫反应性CD4 + T细胞比例较低。

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