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首页> 外文期刊>Infection and immunity >Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum.
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Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum.

机译:恶性疟原虫体外刺激人巨噬细胞产生的肿瘤坏死因子。

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Production of tumor necrosis factor by human macrophages may be induced in vitro by cytoadherent and noncytoadherent strains of Plasmodium falciparum, with an optimal ratio of one to three parasitized erythrocytes per macrophage. Centrifuged and heated crude culture supernatants have the same effect, thus showing the existence of a thermostable soluble factor able to induce this expression. In vitro kinetic experiments have shown that the secretion of tumor necrosis factor appears early, with a maximal peak at 8 h.
机译:人巨噬细胞产生的肿瘤坏死因子可以由恶性疟原虫的细胞粘附和非细胞粘附菌株在体外诱导,每个巨噬细胞的最佳比例为一到三个寄生红细胞。离心和加热的粗培养上清液具有相同的作用,因此表明存在能够诱导该表达的热稳定可溶性因子。体外动力学实验表明,肿瘤坏死因子的分泌较早出现,最大峰值出现在8 h。

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