...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived.
【24h】

Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived.

机译：人对恶性疟原虫主要裂殖子表面抗原的抗体反应是菌株特异性的且寿命短。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The precursor of the major merozoite antigen of Plasmodium falciparum, gp190, is considered a candidate for inclusion in a malaria vaccine. This protein, which consists of conserved, dimorphic, and polymorphic sequences, is very immunogenic in humans. In a longitudinal study carried out with 94 inhabitants of a rural community in Mali, West Africa, we show that in this endemic area naturally acquired gp190-specific antibodies are predominantly directed against the dimorphic parts of one of the main alleles of gp190. The presence of antibodies against these dimorphic regions correlates with the prevalence of the corresponding antigen in the infecting parasite population. Moreover, qualitative as well as quantitative differences were found in the time course of the humoral immune response to the dimorphic regions in adults and children, who differ in their susceptibility to malaria infection.
机译：恶性疟原虫主要裂殖子抗原的前体，gp190，被认为是包含在疟疾疫苗中的候选物。这种蛋白质由保守的，双态的和多态的序列组成，在人类中具有很高的免疫原性。在与西非马里一个农村社区的94位居民进行的纵向研究中，我们表明，在该流行地区，自然获得的gp190特异性抗体主要针对gp190的主要等位基因之一的双态部分。针对这些双态区的抗体的存在与感染的寄生虫种群中相应抗原的流行有关。此外，在成年人和儿童对二形区的体液免疫反应的时间过程中，发现了质和量的差异，他们对疟疾感染的敏感性不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号