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首页> 外文期刊>Infection and immunity >Adherence of Nocardia asteroides within the murine brain.
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Adherence of Nocardia asteroides within the murine brain.

机译：鼠脑中诺卡氏小行星的粘附。

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Nonlethal infection of BALB/c mice with Nocardia asteroides GUH-2 (GUH-2) produces a variety of neurological signs, including an L-dopa-responsive movement disorder in 10 to 15% of the infected population. To study nocardial interactions with the brain, we characterized the attachment of GUH-2 within specific regions through the use of microdissection. Following an intravenous injection of a single-cell suspension of log-phase GUH-2, viable cells were recovered from all regions of the brain, and the distribution of the nocardiae was independent of the size of the inoculum. In addition, two mutants of GUH-2 were found to possess significantly altered binding characteristics with regard to both the percentage of the inoculum bound per brain and the relative distribution of adherence to regions of the brain, when compared with the parental strain. These results indicated that GUH-2 bound throughout the murine brain and suggested that GUH-2 utilized specific receptors to facilitate this attachment.
机译：非致死性小行星诺卡氏菌GUH-2（GUH-2）对BALB / c小鼠的非致死性感染可产生多种神经系统症状，包括10％至15％的受感染人群发生L-多巴反应性运动障碍。为了研究诺卡迪与大脑的相互作用，我们通过使用显微解剖来表征GUH-2在特定区域内的附着。静脉注射对数期GUH-2的单细胞悬液后，从大脑的所有区域回收了活细胞，诺卡氏菌的分布与接种物的大小无关。另外，当与亲本菌株相比时，发现两个GUH-2突变体在每个脑中结合的接种物的百分比和粘附于大脑区域的相对分布方面具有明显改变的结合特性。这些结果表明GUH-2结合整个鼠脑，并暗示GUH-2利用特定的受体来促进这种附着。

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