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首页> 外文期刊>Infection and immunity >Immune and pathologic responses in mice infected with Brucella abortus 19, RB51, or 2308.
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Immune and pathologic responses in mice infected with Brucella abortus 19, RB51, or 2308.

机译：感染流产布鲁氏菌19，RB51或2308的小鼠的免疫和病理反应。

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Immune and pathologic responses were measured for 20 weeks after infection of mice with Brucella abortus 19, RB51, or 2308. Live bacteria and bacterial antigens of 19 and RB51 persisted in spleens for 10 and 4 weeks after infection, respectively, whereas 2308 bacteria and bacterial antigens persisted for at least 20 weeks. Small germinal centers and profound lymphoid depletion occurred in spleens of mice during the first 4 weeks of infection with strain 19 or 2308; however, mice infected with strain RB51 had much larger germinal centers but no lymphoid depletion. At 4 weeks, only spleen cells from RB51-infected mice proliferated when incubated with 2308 bacteria. Large germinal centers in the spleen and spleen cell proliferative responses to 2308 did not appear in strain 19-infected mice until 6 weeks or in strain 2308-infected mice until 10 weeks. Similar proliferative responses to 2308 occurred in mice infected with strain 19 or RB51 at 6 weeks and in mice infected with strain 19, RB51, or 2308 at 10 weeks. However, at 20 weeks, spleen cell proliferative responses to 2308 occurred in mice infected with strain 19 or 2308 but not in mice infected with strain RB51. Mice infected with strain RB51 had lower and less persistent antibody titers to 2308 than did mice infected with strain 19 or 2308. Collectively, these results indicate that RB51-infected mice have less persistent immune responses to 2308 than do mice infected with 19 or 2308. The shorter duration of the responses probably resulted because RB51 is considerably less pathogenic and is cleared more rapidly from mice than are 19 and 2308.
机译：在流产布鲁氏菌19，RB51或2308的小鼠感染后20周，测定免疫和病理反应。感染后，脾脏中的活细菌和细菌抗原19和RB51分别持续存在10和4周，而细菌和细菌则有2308抗原持续至少20周。在19或2308毒株感染的最初4周内，小鼠的脾脏中出现了小的生发中心和严重的淋巴样耗竭。但是，感染RB51株的小鼠生发中心更大，但没有淋巴样消耗。在第4周，与2308种细菌孵育后，只有来自RB51感染小鼠的脾细胞增殖。直到19周之前，在小鼠中脾和脾细胞对2308的增殖反应中的大的生发中心直到6周才出现，或者直到10周之前，在小鼠2308中才出现。在第6周感染了19菌株或RB51的小鼠和在第10周感染了19菌株，RB51或2308的小鼠发生了对2308的相似增殖反应。但是，在20周时，在感染19或2308株的小鼠中发生了对2308的脾细胞增殖反应，但没有在感染RB51株的小鼠中发生。感染RB51的小鼠的抗体效价比感染19或2308的小鼠更低，持久抗体效价更低。这些结果表明，感染RB51的小鼠对2308的持久免疫应答比感染19或2308的小鼠低。响应时间较短可能是因为RB51的致病性大大降低，并且与19和2308相比，从小鼠中清除的速度更快。

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