Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs.

F Daigle; J M Fairbrother; J Harel

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Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs.

机译：鉴定了pst-phoU操纵子中的一种突变，该突变可降低导致猪败血症的大肠杆菌菌株的致病性。

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We used transposon (TnphoA) mutagenesis to study the role of virulence factors of pathogenic Escherichia coli strains associated with septicemia in calves and piglets. We have produced an avirulent and serum-sensitive mutant of wild-type pathogenic strain 5131 O115:K"V165":F165 and have localized and identified the TnphoA insertion in the pstC gene of the pst-phoU operon. This operon encodes the PstSCAB transporter and PhoU protein that negatively regulate the phosphate (Pho) regulon. This mutation is pleiotropic and could have an effect on pathogenicity and on the production of the surface polysaccharides of strain 5131. The mutant demonstrated restored repressibility of alkaline phosphatase and regained the capacity to resist serum and to survive systemically for at least 5 days in experimentally inoculated pigs when complemented with plasmid pAN92, bearing the pst-phoU operon.

机译：我们使用转座子（TnphoA）诱变研究了犊牛和仔猪中与败血病相关的致病性大肠杆菌菌株毒力因子的作用。我们已经产生了一种野生型致病性菌株5131 O115：K“ V165”：F165的无毒且血清敏感的突变体，并在pst-phoU操纵子的pstC基因中定位并鉴定了TnphoA插入。该操纵子编码PstSCAB转运蛋白和PhoU蛋白，它们负调控磷酸（Pho）调节子。该突变是多效性的，并且可能对5131菌株的致病性和表面多糖的产生产生影响。该突变体表现出恢复的碱性磷酸酶的阻遏性，并在实验接种后恢复了抗血清和全身存活至少5天的能力。猪与质粒pAN92互补后，带有pst-phoU操纵子。

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《Infection and immunity》 |1995年第12期|共4页
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F Daigle; J M Fairbrother; J Harel;
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中图分类医学免疫学;
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1. Isolation, identification, and pathogenicity of O142 avian pathogenic Escherichia coli causing black proventriculus and septicemia in broiler breeders [J] . Wang Xiaobo, Cao Chunguang, Huan Haixia, Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2015,第Null期

机译：O142禽病原性大肠杆菌的分离，鉴定和致病性，可引起肉鸡饲养者的黑色前列腺炎和败血病
2. Pathogenicity of an Escherichia coli O115:K"V165" mutant negative for F165(1) fimbriae in septicemia of gnotobiotic pigs. [J] . M Ngeleka, M Jacques, B Martineau-Doizé, Infection and immunity . 1993,第3期

机译：大肠埃希氏菌败血症中F165（1）菌毛阴性的大肠杆菌O115：K“ V165”突变体的致病性。
3. The lethal phenotype caused by null mutations in the Escherichia coli htrB gene is suppressed by mutations in the accBC operon, encoding two subunits of acetyl coenzyme A carboxylase. [J] . M Karow, O Fayet, C Georgopoulos Journal of bacteriology . 1992,第22期

机译：大肠杆菌htrB基因无效突变引起的致死表型被accBC操纵子中的突变所抑制，该突变体编码乙酰辅酶A羧化酶的两个亚基。
4. Pathogenic Escherichia Coli Strains [C] . Rabih E. Jabbour, Raja Sekhar Nirujogi, Min-Sik Kim, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：病原大肠杆菌大肠杆菌菌株
5. Identification of genomic differences between Escherichia coli strains pathogenic for poultry and E. coli K-12 MG1655. [D] . Stocki, Stacy Lynn. 2003

机译：鉴定家禽致病性大肠杆菌菌株与大肠杆菌K-12 MG1655之间的基因组差异。
6. Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs. [O] . F Daigle, J M Fairbrother, J Harel 1995

机译：鉴定了pst-phoU操纵子中的一种突变该突变可降低导致猪败血症的大肠杆菌菌株的致病性。
7. Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs [O] . F Daigle, J M Fairbrother, J Harel 1995

机译：鉴定PST-Phou操纵子中的突变，降低了导致猪败血症的大肠杆菌菌株的致病性

Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs.

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