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首页> 外文期刊>Infection and immunity >Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass.
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Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass.

机译：人对恶性疟原虫裂殖子表面蛋白2的抗体反应是血清群特异性的，并且主要是免疫球蛋白G3亚类的。

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MSP2 is a merozoite surface protein of Plasmodium falciparum and, as such, is a potential component of a malaria vaccine. In this study, we have used a panel of recombinant MSP2 antigens in enzyme-linked immunosorbent assays to investigate the recognition of MSP2 by antibodies from malaria-immune human serum. These recombinant antigens include full-length proteins of serogroups A and B and fragments representing the conserved, group-specific, or repeat regions of each serogroup. Ninety-five percent of the serum samples tested contained MSP2-specific antibodies: 81% of serum samples tested responded to serogroup A, and 86% responded to serogroup B. The antibody response is directed almost exclusively towards dimorphic and polymorphic regions of MSP2; the conserved regions are rarely recognized, and antibodies to serogroups A and B do not cross-react. Interestingly, the antibody response is predominately of the cytophilic and complement-fixing subclass immunoglobulin G3.
机译：MSP2是恶性疟原虫的裂殖子表面蛋白，因此，它是疟疾疫苗的潜在成分。在这项研究中，我们在酶联免疫吸附测定中使用了一组重组MSP2抗原，以研究来自疟疾免疫人血清的抗体对MSP2的识别。这些重组抗原包括血清群A和B的全长蛋白，以及代表每个血清群保守，组特异性或重复区域的片段。 95％的血清样品包含MSP2特异性抗体：81％的血清样品对A血清组有反应，而86％的血清B对血清组有反应。抗体反应几乎完全针对MSP2的双态和多态区域。保守区很少被识别，血清群A和B的抗体不会交叉反应。有趣的是，抗体应答主要是嗜细胞和补体固定亚类免疫球蛋白G3。

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