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首页> 外文期刊>Infection and immunity >Immunoglobulin allotypes and immunoglobulin G subclass responses to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in early-onset periodontitis.
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Immunoglobulin allotypes and immunoglobulin G subclass responses to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in early-onset periodontitis.

机译：在早发性牙周炎中，对放线放线杆菌和牙龈卟啉单胞菌的免疫球蛋白同种异型和免疫球蛋白G亚类反应。

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摘要

The present study was performed to estimate the observed frequencies of the immunoglobulin heavy-chain (Gm) and light-chain (Km) allotypes among patients with early-onset periodontitis (EOP) and their effect on the IgG2 subclass responses against Actinobacillus actinomycetemcomitans Y4 and Porphyromonas gingivalis 381, respectively. Sixty-nine EOP patients, including 11 with localized juvenile periodontitis (LJP), 19 who had LJP, 15 with LJP-rapidly progressing periodontitis (RPP), and 24 with RPP, were examined for the Gm and Km allotypes by a hemagglutination inhibition test. Levels of immunoglobulin G2 (IgG2) antibodies against the two organisms were determined by enzyme-linked immunosorbent assay. Fifty race- and age-matched, periodontally healthy subjects were also included as a control group. The observed frequencies of the Gm haplotype afnb and Km(1) were significantly higher in the RPP and LJP groups, respectively. The G2m(n)+ group of those with RPP and the Km(1)+ group of those with LJP had significantly higher levels of IgG2 antibodies to A. actinomycetemcomitans and P. gingivalis, respectively. The results indicate that linkage disequilibrium of the G2m(n) locus in RPP patients or the Km(1) locus in LJP patients may be associated with high IgG2 antibody responses to the respective bacteria. It was reasoned that the IgG2 antibody responses are associated with the immunoglobulin allotypes. The function of IgG2 antibodies in their reaction to different bacterial antigens may be interpreted as either protective or nonprotective in the two different types of EOP (i.e., LJP and RPP).
机译：进行本研究是为了估计早发性牙周炎（EOP）患者中免疫球蛋白重链（Gm）和轻链（Km）同种异型的观察频率及其对IgG2亚类对放线放线杆菌放线杆菌Y4和牙龈卟啉单胞菌381。通过血凝抑制试验检查了69例EOP患者，包括11例局部性少年牙周炎（LJP），19例LJP，15例LJP快速进展性牙周炎（RPP​​）和24例RPP，对他们的Gm和Km同种异型进行了检查。通过酶联免疫吸附测定来确定针对这两种生物的免疫球蛋白G2（IgG2）抗体水平。五十名与种族和年龄相匹配的牙周健康受试者也被作为对照组。在RPP和LJP组中，观察到的Gm单倍型afnb和Km（1）的频率显着更高。患有RPP的患者的G2m（n）+组和患有LJP的患者的Km（1）+组分别具有较高的抗放线杆菌和牙龈卟啉单胞菌IgG2抗体水平。结果表明，RPP患者中G2m（n）基因座或LJP患者中Km（1）基因座的连锁不平衡可能与对相应细菌的IgG2抗体应答高有关。有理由认为，IgG2抗体应答与免疫球蛋白同种异型有关。 IgG2抗体在与不同细菌抗原的反应中的功能可以解释为在两种不同类型的EOP（即，LJP和RPP）中是保护性的或非保护性的。

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