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OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks.

机译：OspA抗体可抑制速虫tick虫对伯氏疏螺旋体的获取。

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Ixodes ticks are infected by Borrelia burgdorferi when larvae feed on spirochete-infected mice. We studied the acquisition of B. burgdorferi by larval ticks, characterized the production of outer surface protein A (OspA) by spirochetes entering larvae, and examined the effects of OspA antibodies on the establishment of B. burgdorferi infections in ticks. Most larvae were infected by spirochetes 24 to 48 h after placement on mice. OspA antibodies stained the first spirochetes observed in larvae, suggesting that OspA is synthesized early during the colonization of the vector. When OspA antibodies were administered to B. burgdorferi-infected mice and larvae were then placed on the animals, the severity of larval infection and the number of infected ticks (7 of 16) were decreased compared with that of controls (15 of 16). The inhibitory effects of OspA antibodies were observed with passive antibody transfer as well as active host-generated immunity. The lower larval infection rate observed in the presence of OspA antibodies was exacerbated after the larval molt since only 1 of 12 nymphs was infected, and none of the mice that were fed upon by these nymphs became infected with B. burgdorferi. Therefore, an OspA antibody response in mice altered the reservoir competence of the vertebrate host by inhibiting the movement of B. burgdorferi from the host to the vector.
机译：当幼虫以螺旋体感染的小鼠为食时，x虫被博氏疏螺旋体感染。我们研究了幼虫tick虫对B. burgdorferi的获取，表征了进入幼虫的螺旋体产生外表面蛋白A（OspA），并研究了OspA抗体对tick虫中B. burgdorferi感染建立的影响。放置在小鼠上后24至48小时，大多数幼虫被螺旋体感染。 OspA抗体染色了幼虫中观察到的第一个螺旋体，表明OspA在载体定植的早期就合成了。当将OspA抗体施用给感染伯氏疏螺旋体的小鼠，然后将幼虫放在动物身上时，与对照组相比（16中的15），幼虫感染的严重程度和被感染的tick的数量（16中的7）降低了。观察到OspA抗体的抑制作用以及被动抗体转移以及主动宿主产生的免疫力。在幼虫蜕皮中，在OspA抗体存在下观察到的较低的幼虫感染率加剧了，因为只感染了12只若虫中的1只，并且由这些若虫喂养的小鼠均未感染伯氏疏螺旋体。因此，小鼠中的OspA抗体应答通过抑制伯氏疏螺旋体从宿主到载体的运动而改变了脊椎动物宿主的贮藏能力。

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