Low Genetic Diversity of Haemophilus influenzae Type b Compared to Nonencapsulated H. influenzae in a Population in Which H. influenzaeIs Highly Endemic

Heidi C. Smith-Vaughan; Kadaba S. Sriprakash; Amanda J. Leach; John D. Mathews; David J. Kemp

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Low Genetic Diversity of Haemophilus influenzae Type b Compared to Nonencapsulated H. influenzae in a Population in Which H. influenzaeIs Highly Endemic

机译：与非封装的流感嗜血杆菌相比，流感嗜血杆菌是地方性流行人群，b型流感嗜血杆菌的遗传多样性低

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Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae(NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.

机译：b型流感嗜血杆菌（Hib）结合多糖疫苗的免疫已大大降低了全世界的Hib疾病。与其他人群一样，接种疫苗后原住民婴儿的Hib鼻咽携带明显减少，尽管尚未完全消除携带。在这项研究中，我们描述了Hib的纵向分离株的遗传特征和运输动力学，通过使用几种分型方法来表征。另外，未封装的 H的载带率。流感（NCHi）很高，常见同时出现Hib和NCHi定植;我们还观察到了与Hib遗传相似的NCHi分离株。持续需要促进Hib免疫和监测H。在该生物高度流行的人群中进行流感运输，这尤其是因为在此类人群中Hib和NCHi菌株之间可能发生基因交换。 展开▼

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《Infection and immunity》 |1998年第7期|共7页

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Heidi C. Smith-Vaughan; Kadaba S. Sriprakash; Amanda J. Leach; John D. Mathews; David J. Kemp;
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中图分类医学免疫学;

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专利

1. Prevalence of Haemophilus influenzae Type b Genetic Islands among Clinical and Commensal H. influenzae and H. haemolyticus Isolates [J] . Sara A. Sandstedt, Carl F. Marrs, Mayuri Patel, Journal of Clinical Microbiology . 2010,第7期

机译：临床和常规流感嗜血杆菌和溶血嗜血杆菌分离株中b型流感嗜血杆菌遗传岛的患病率

2. Four and one-half-year follow-up of the effectiveness of diphtheria-tetanus toxoids-acellular pertussis/Haemophilus influenzae type b and diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus/H. influenzae type b combination vaccines [J] . Kalies H, Verstraeten T, Grote V, The Pediatric infectious disease journal . 2004,第10期

机译：对白喉-破伤风类毒素-无细胞百日咳/流感嗜血杆菌和白喉-破伤风类毒素-无细胞百日咳-灭活脊髓灰质炎病毒/ H的有效性进行四年和半年的随访。乙型流感混合疫苗

3. Changes in serotype distribution of Haemophilus influenzae meningitis isolates identified through laboratory-based surveillance following routine childhood vaccination against H. influenzae type b in Brazil. [J] . Zanella RC, Bokermann S, Andrade AL, Vaccine . 2011,第48期

机译：在巴西常规接种儿童乙型流感嗜血杆菌疫苗后，通过实验室监测确定了流感嗜血杆菌脑膜炎分离株血清型分布的变化。

4. The effect of PDT on H. influenzae biofllm in vivo [C] . Chung-Ku Rhee, So-Young Chang, Dong-Jo Hwang, Photonic therapeutics and diagnostics VI . 2010

机译：PDT对体内流感嗜血杆菌生物膜的影响

5. Genetic Diversity, Population Structure, and Virulence Gene Polymorphisms in Nontypeable Haemophilus influenzae [D] . LaCross, Nathan C. 2011

机译：不可分型流感嗜血杆菌的遗传多样性，种群结构和毒力基因多态性。

6. Low Genetic Diversity of Haemophilus influenzae Type b Compared to Nonencapsulated H. influenzae in a Population in Which H. influenzae Is Highly Endemic [O] . Heidi C. Smith-Vaughan, Kadaba S. Sriprakash, Amanda J. Leach, 1998

机译：与未封装的流感嗜血杆菌相比在流感嗜血杆菌高度流行的人群中b型流感嗜血杆菌的遗传多样性低

7. Prevalence of Haemophilus influenzae Type b Genetic Islands among Clinical and Commensal H. influenzae and H. haemolyticus Isolates▿ [O] . Sandstedt, Sara A., Marrs, Carl F., Patel, Mayuri, 2010

机译：临床和常规流感嗜血杆菌和溶血嗜血杆菌分离株中b型流感嗜血杆菌遗传岛的患病率▿

1. b型流感嗜血杆菌疫苗接种15年后意大利儿童口咽部流感嗜血杆菌带菌情况及分离株的分子流行病学 [J] . . 微生物学免疫学进展 . 2017,第001期

2. 中国流感嗜血杆菌流行趋势与疫苗免疫决策--2005年中国b型流感嗜血杆菌疾病及其免疫预防高层研讨会纪要 [J] . 朱启镕 ,杨永弘 ,刁连东 . 中华流行病学杂志 . 2005,第012期

3. 国产b型流感嗜血杆菌结合疫苗和进口b型流感嗜血杆菌结合疫苗副反应的观察 [J] . 潘慧远 . 中国医疗前沿 . 2013,第004期

4. 国产b型流感嗜血杆菌结合疫苗和进口b型流感嗜血杆菌结合疫苗副反应的观察 [J] . 潘慧远 . 中国医疗前沿 . 2013,第004期

5. 复合多聚酶链反应技术在流感嗜血杆菌和b型流感嗜血杆菌联合检测中的意义 [J] . 陈志敏 ,汪天林 ,尚世强 . 浙江医学 . 2001,第005期

6. AC群脑膜炎球菌－b型流感嗜血杆菌多糖结合疫苗人群免疫学效果观察 [C] . 李亚南 ,梁丽 ,李艳萍 . 2012年中国药学大会暨第十二届中国药师周 . 2012

7. 中国川西地区住院儿童流感嗜血杆菌感染流行病学研究 [A] . 胡俊 . 2015

1. 基于流感嗜血杆菌表面蛋白抗体的流感嗜血杆菌Elisa检测试剂盒及制备方法 [P] . 中国专利： CN110540598B . 2021.04.30

2. 基于流感嗜血杆菌表面蛋白抗体的流感嗜血杆菌Elisa检测试剂盒及制备方法 [P] . 中国专利： CN110540598A . 2019-12-06

3. H. influenzae detection method, H. influenzae detection primer set and H. influenzae detection kit [P] . 外国专利： JP5019431B2 . 2012-09-05

机译：流感嗜血杆菌检测方法，流感嗜血杆菌检测引物组和流感嗜血菌检测试剂盒

4. Non-typeable haemophilus influenzae p4 variant protein, immunogenic composition, isolated nucleotide molecule, host cell, and methods for inducing an immune response in a human against h. non-typifiable influenzae, and to produce a variant protein of p4 [P] . 外国专利： BR0308441A . 2005-01-18

机译：不可分型流感嗜血杆菌p4变体蛋白，免疫原性组合物，分离的核苷酸分子，宿主细胞和诱导人类针对h的免疫应答的方法。非典型流感，并产生p4变异蛋白

5. Vaccine compositions comprising Pw, TT, DT and H. influenzae type B (Hib) with a lower dose of Hib (5 mcg) compared with the standard does (10 mcg) [P] . 外国专利： NZ523319A . 2006-01-27

机译：包含Pw，TT，DT和B型流感嗜血杆菌（Hib）的疫苗组合物，其Hib剂量（5 mcg）低于标准剂量（10 mcg）

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Low Genetic Diversity of Haemophilus influenzae Type b Compared to Nonencapsulated H. influenzae in a Population in Which H. influenzaeIs Highly Endemic

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