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首页> 外文期刊>Infection and immunity >An Essential Role for Interleukin-5 and Eosinophils in Helminth-Induced Airway Hyperresponsiveness
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An Essential Role for Interleukin-5 and Eosinophils in Helminth-Induced Airway Hyperresponsiveness

机译：白介素5和嗜酸性粒细胞在蠕虫诱导的气道高反应性中的重要作用

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Infection with the parasitic helminth Brugia malayi can result in development of a severe asthmatic response termed tropical pulmonary eosinophilia. This disease, thought to result from a host inflammatory response to blood parasites which become trapped in the lung microvasculature, is characterized by a profound eosinophilic infiltration into the lungs. Recruitment of eosinophils also correlates with the development of airway hyperresponsiveness (AHR) to cholinergic agonists and severe asthmatic symptoms. Our studies examined the role of interleukin-5 (IL-5) in helminth-induced pulmonary eosinophilia and AHR. C57BL/6 mice immunized with killed B. malayi microfilariae and challenged intravenously with live microfilariae exhibit many of the characteristics of human disease, including peripheral and pulmonary eosinophilia. Cells recovered by bronchoalveolar lavage of sensitized mice consisted of 3.8% eosinophils on day 1 postchallenge and 84% on day 10. Extracellular major basic protein was present on the surface of airway epithelial cells as early as day 1 and continued to be evident after 8 days, indicating sustained activation and degranulation of eosinophils in the lung. These histologic changes correlated with the development of AHR to carbachol. In contrast to immunocompetent mice, immunization and challenge with B. malayi in IL-5?/? mice did not induce peripheral or pulmonary eosinophilia, and these mice failed to show AHR in response to cholinergic agonists. Taken together, these data indicate that IL-5 and eosinophils are required for the induction of AHR by filarial helminths.
机译：感染寄生性蠕虫 Brugia malayi 会导致严重的哮喘反应，称为热带肺嗜酸性粒细胞增多。这种疾病被认为是由于宿主对血液寄生虫的炎症反应所致，而血液寄生虫则被困在肺微脉管系统中，其特征是嗜酸性粒细胞浸润到肺中。嗜酸性粒细胞的募集也与对胆碱能激动剂和严重哮喘症状的气道高反应性（AHR）的发展有关。我们的研究检查了白介素5（IL-5）在蠕虫诱导的肺嗜酸性粒细胞增多和AHR中的作用。用杀死的 B免疫的C57BL / 6小鼠。马拉微丝虫和静脉注射活丝虫具有人类疾病的许多特征，包括周围和肺部嗜酸性粒细胞增多。致敏小鼠支气管肺泡灌洗恢复的细胞在攻击后第1天由3.8％的嗜酸性粒细胞组成，在第10天由84％的细胞组成。胞外主要碱性蛋白最早在第1天就存在于气道上皮细胞表面，并在8天后继续明显，表明肺中嗜酸性粒细胞持续活化和脱粒。这些组织学变化与AHR向卡巴胆碱的发展有关。与具有免疫能力的小鼠相反，使用 B进行免疫和攻击。 IL-5 ？/？小鼠中的malayi 没有诱导外周或肺嗜酸性粒细胞增多，并且这些小鼠对胆碱能激动剂的反应均未显示出AHR。综上所述，这些数据表明IL-5和嗜酸性粒细胞是通过丝虫诱导AHR所必需的。

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