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首页> 外文期刊>Infection and immunity >Antrum- and Corpus Mucosa-Infiltrating CD4+ Lymphocytes in Helicobacter pyloriGastritis Display a Th1 Phenotype
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Antrum- and Corpus Mucosa-Infiltrating CD4+ Lymphocytes in Helicobacter pyloriGastritis Display a Th1 Phenotype

机译：幽门螺杆菌胃窦和Corp体粘膜浸润CD4 +淋巴细胞胃炎显示Th1表型。

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In this study, cytokine patterns produced by CD4+ T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4+ T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4+ cells were not detected. Therefore, CD4+ cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pyloriinfection.
机译：本研究比较了10例幽门螺杆菌阳性胃炎患者胃窦或胃体胃活检标本中分离的CD4 + T细胞产生的细胞因子模式。为此，通过流式细胞术评估细胞内细胞因子（白介素4 [IL-4]和γ干扰素）和CD4的表达。刺激后，分离出的CD4 + T细胞中有10％至60％产生了γ干扰素。除一名患者外，未检测到IL-4阳性CD4 + 细胞。因此，在 H期间，CD4 + 细胞浸润胃窦和胃粘膜。幽门螺杆菌感染表现出Th1表型。这种极化的Th1型应答可能导致免疫系统无法根除 H。幽门螺杆菌感染。

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