Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

Michel Arock; Elaine Ross; René Lai-Kuen; Geneviève Averlant; Zhimin Gao; Soman N. Abraham

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Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

机译：暴露于革兰氏阴性和革兰氏阳性细菌后人肥大细胞的吞噬和肿瘤坏死因子α反应

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Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

机译：最近的研究已将啮齿类动物肥大细胞牵涉到对感染细菌的先天免疫反应。我们报告说，从脐带血祖细胞的培养物中获得的脐带血来源的人类肥大细胞（CBHMC）被吞噬并杀死了各种革兰氏阴性和革兰氏阳性细菌，同时释放了大量的肿瘤坏死因子α。总体而言，CBHMC的内吞和胞外反应程度与附着细菌的数量有关。因此，人类肥大细胞固有地能够介导微生物识别并主动促进宿主抵抗细菌的防御。

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《Infection and immunity》 |1998年第12期|共5页
作者
Michel Arock; Elaine Ross; René Lai-Kuen; Geneviève Averlant; Zhimin Gao; Soman N. Abraham;
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中图分类医学免疫学;
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1. Lactic Acid Bacteria Inducing a Weak Interleukin-12 and Tumor Necrosis Factor Alpha Response in Human Dendritic Cells Inhibit Strongly Stimulating Lactic Acid Bacteria but Act Synergistically with Gram-Negative Bacteria [J] . Louise Hjerrild Zeuthen, Hanne Risager Christensen, Hanne Fr?ki?r Clinical and vaccine immunology: CVI . 2006,第3期

机译：乳酸菌在人树突状细胞中诱导弱的白介素12和肿瘤坏死因子α反应抑制强烈刺激乳酸菌，但与革兰氏阴性菌协同作用。
2. Differential Tumor Necrosis Factor Alpha Expression and Release from Peritoneal Mouse Macrophages In Vitro in Response to Proliferating Gram-Positive versus Gram-Negative Bacteria [J] . Wei Cui, David C. Morrison, Richard Silverstein Infection and immunity . 2000,第8期

机译：分化的肿瘤坏死因子α表达和体外响应于增殖革兰氏阳性细菌与革兰氏阴性细菌从腹膜小鼠巨噬细胞释放。
3. Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice. [J] . M A Freudenberg, C Galanos Infection and immunity . 1991,第6期

机译：肿瘤坏死因子α介导D-半乳糖胺治疗的小鼠中被杀死的革兰氏阴性和革兰氏阳性细菌的致死活性。
4. Effect of CV6209, A platelet-activating factor antagonist, on shiga toxin-induced tumor necrosis factor-alpha expression in human monocytic cells [C] . Hui-Min Zhang, Tatsuo Yamamoto 7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai . 2000

机译：血小板活化因子拮抗剂CV6209对芝加毒素诱导的人单核细胞中肿瘤坏死因子-α表达的影响
5. Intracellular Signal Transduction Mechanisms Regulating the Activation of Human Bronchial Epithelial Cells by Interleukin-17A, Interleukin-27, Tumor Necrosis Factor-alpha and Human Basophils in Inflammatory Diseases [D] . Cao, Ju 2010

机译：调节人白细胞介素17A，白细胞介素27，肿瘤坏死因子-α和人类嗜碱性粒细胞在炎性疾病中激活人支气管上皮细胞的细胞内信号转导机制
6. Note: Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria [O] . Michel Arock, Elaine Ross, René Lai-Kuen, 1998

机译：注意：暴露于革兰氏阴性和革兰氏阳性细菌后人肥大细胞的吞噬和肿瘤坏死因子α反应
7. Lactic Acid Bacteria Inducing a Weak Interleukin-12 and Tumor Necrosis Factor Alpha Response in Human Dendritic Cells Inhibit Strongly Stimulating Lactic Acid Bacteria but Act Synergistically with Gram-Negative Bacteria [O] . Zeuthen, Louise Hjerrild, Christensen, Hanne Risager, Frøkiær, Hanne 2006

机译：乳酸菌在人树突状细胞中诱导弱的白介素12和肿瘤坏死因子α反应抑制强烈刺激乳酸菌，但与革兰氏阴性菌协同作用。
8. IL-1 and Tumor Necrosis Factor-Alpha Each Up-Regulate Both the Expression of IFN-Gamma Receptors and Enhance IFN-Gamma-Induced HLA-DR Expression on Human Monocytes and a Human Monocytic Cell Line (THP-1) [R] . Krakauer, T., Oppenheim, J. J. 1993

机译：IL-1和肿瘤坏死因子-α各自上调IFN-γ受体的表达并增强人单核细胞和人单核细胞系（THp-1）上IFN-γ诱导的HLa-DR表达

Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

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