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首页> 外文期刊>Infection and immunity >Isolation of Enterococcus faecalis Clinical Isolates That Efficiently Adhere to Human Bladder Carcinoma T24 Cells and Inhibition of Adhesion by Fibronectin and Trypsin Treatment
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Isolation of Enterococcus faecalis Clinical Isolates That Efficiently Adhere to Human Bladder Carcinoma T24 Cells and Inhibition of Adhesion by Fibronectin and Trypsin Treatment

机译：有效分离人膀胱癌T24细胞的粪肠球菌临床分离株以及纤连蛋白和胰蛋白酶治疗抑制黏附

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The adherence of Enterococcus faecalis strains to human T24 cells was examined by scanning electron microscopy. Five highly adhesive strains were identified from 30 strains isolated from the urine of patients with urinary tract infections. No efficiently adhesive strains were found among the 30 strains isolated from the feces of healthy students. The five isolated strains also adhered efficiently to human bladder epithelial cells. Analysis of restriction endonuclease-digested plasmid DNAs and chromosome DNAs showed that the five strains were different strains isolated from different patients. The adhesiveness of these strains was inhibited by treatment with fibronectin or trypsin, implying that a specific protein (adhesin) on the bacterial cell surface mediates adherence to fibronectin on the host cell surfaces, and the adhesin differs from the reported adhesins.
机译：用扫描电镜观察粪肠球菌对人T24细胞的粘附。从尿路感染患者尿液中分离出的30株菌株中，鉴定出5种高粘附力菌株。从健康学生的粪便中分离出的30种菌株中没有发现有效的粘附菌株。五个分离的菌株也有效地粘附于人膀胱上皮细胞。限制性核酸内切酶消化的质粒DNA和染色体DNA的分析表明，这五个菌株是从不同患者中分离出的不同菌株。这些菌株的粘着性受到纤连蛋白或胰蛋白酶处理的抑制，这意味着细菌细胞表面的特定蛋白（黏附素）介导了宿主细胞表面对纤连蛋白的黏附，而黏附素与所报道的黏附素有所不同。

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