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Five Homologous Repeats of the Protein G-Related Protein MIG Cooperate in Binding to Goat Immunoglobulin G

机译:蛋白G相关蛋白MIG的五个同源重复合作与山羊免疫球蛋白G结合。

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摘要

Protein MIG, from Streptococcus dysgalactiae, binds α2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000-fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.
机译:来自链球菌dysgalactiae 的蛋白MIG结合α 2 -巨球蛋白和免疫球蛋白G(IgG)。具有1-5个IgG结合重复序列的MIG衍生融合蛋白对山羊IgG的亲和力差异高达72,000倍,表明这些重复序列具有相当大的协同性。识别出IgG结合重复序列的显着序列变化。 MIG蛋白通过Fc和Fab部分与山羊IgG1相互作用。

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