Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a LiveSalmonella enterica Serovar Typhimurium Vaccine Strain

Heloisa C. R. Guillobel; Joana I. Carinhanha; Lucia Cárdenas; John D. Clements; Darcy F. de Almeida; Luís C. S. Ferreira

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Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a LiveSalmonella enterica Serovar Typhimurium Vaccine Strain

机译：大肠杆菌热不稳定肠毒素的无毒突变体对肠道沙门氏菌血清型鼠伤寒疫苗株携带的异源抗原引起的全身和粘膜免疫应答的佐剂活性。

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Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenicEscherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT_(R192G). The results further support the adjuvant effects of LT_(R192G) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.

机译：对产肠毒素的大肠杆菌（ETEC）的定殖因子抗原I（CFA / I）的主要亚基和重组二价沙门氏菌表达的体脂多糖的全身和粘膜抗体反应联合使用脱毒衍生物和保留的ETEC热不稳定毒素LT _{（R192G）的佐剂可以显着增强疫苗株。结果进一步支持了LT _{（R192G）的佐剂作用，并代表了一种简单的替代方法，可以改善针对口服递送的沙门氏菌疫苗株表达的对客运抗原的应答。}} 展开▼

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《Infection and immunity》 |2000年第7期|共5页

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Heloisa C. R. Guillobel; Joana I. Carinhanha; Lucia Cárdenas; John D. Clements; Darcy F. de Almeida; Luís C. S. Ferreira;
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中图分类医学免疫学;

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1. Enhancement of Immune Responses by an Attenuated Salmonella enterica Serovar Typhimurium Strain Secreting an Escherichia coli Heat-Labile Enterotoxin B Subunit Protein as an Adjuvant for a Live Salmonella Vaccine Candidate [J] . Jin Hur, John Hwa Lee Clinical and vaccine immunology: CVI . 2011,第2期

机译：减毒肠炎沙门氏菌血清型鼠伤寒沙门氏菌菌株的分泌，该菌株分泌大肠杆菌热不稳定肠毒素B亚基蛋白作为活沙门氏菌疫苗候选者的佐剂

2. Levels of Expression and Immunogenicity of Attenuated Salmonella enterica Serovar Typhimurium Strains Expressing Escherichia coli Mutant Heat-Labile Enterotoxin [J] . M. Giuseppina Covone, Marcelo Brocchi, Emanuela Palla, Infection and immunity . 1998,第1期

机译：表达大肠杆菌突变热不稳定肠毒素的减毒小肠沙门氏菌鼠伤寒沙门氏菌的表达水平和免疫原性

3. Mutants of Escherichia coli Heat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells [J] . Elizabeth J. Ryan, Edel McNeela, Geraldine A. Murphy, Infection and immunity . 1999,第12期

机译：大肠杆菌热不稳定毒素突变体作为无黏膜百日咳疫苗经鼻递送的有效粘膜佐剂：无毒AB复合物和酶活性对Th1和Th2细胞的差异作用

4. Construction and characterization of a non-toxic mutant of the Escherichia coli heat-labile enterotoxin effective as an oral adjuvant. [D] . Dickinson, Bonny Lynn. 1995

机译：大肠杆菌热不稳定肠毒素的无毒突变体的构建和表征，该突变体可有效用作口服佐剂。

5. Note: Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a Live Salmonella enterica Serovar Typhimurium Vaccine Strain [O] . Heloisa C. R. Guillobel, Joana I. Carinhanha, Lucia Cárdenas, 2000

机译：注意：大肠杆菌热不稳定肠毒素的无毒突变体对活肠沙门氏菌血清型鼠伤寒疫苗株携带的异源抗原引起的全身和粘膜免疫反应的佐剂活性。

6. Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a Live Salmonella enterica Serovar Typhimurium Vaccine Strain [O] . Guillobel, Heloisa C. R., Carinhanha, Joana I., Cárdenas, Lucia, 2000

机译：大肠杆菌热不稳定肠毒素的无毒突变体对活肠沙门氏菌血清型鼠伤寒疫苗株携带的异源抗原引起的全身和粘膜免疫应答的佐剂活性。

1. 大肠杆菌热不稳定肠毒素无毒突变体LTR72基因重组质粒的构建 [J] . 葛艳 ,尤永进 ,徐泉兴 . 上海农业学报 . 2003,第004期

2. 一种粘膜免疫佐剂--大肠杆菌热不稳定肠毒素研究现况 [J] . 杨德琴 . 国际免疫学杂志 . 2004,第001期

3. 粘膜佐剂大肠杆菌不耐热肠毒素无毒突变体mLT63及CpG-ODN的鼻内免疫效果研究 [C] . 王冠 ,段广才 ,张庶民 . 第六次全国医学分子微生物学及生物技术研讨会 . 2006

1. VACCINE CONTAINING AT LEAST ONE PARTICULATE IMMUNOGEN AND ADJUVANTING AMOUNT OF SUBUNITS OF e. COLI HEAT-LABILE ENTEROTOXIN (LTB) FREE FROM CONTAMINATING A SUBUNITS OR TOXIC HOLOTOXIN, ITS USE FOR INDUCTION OF LOCAL AND SYSTEMIC PROTECTIVE RESPONSE AGAINST PARTICULATE IMMUNOGEN UPON MUCOSAL ADMINISTRATION [P] . 外国专利： UA72199C2 . 2005-02-15

机译：至少含一种微粒免疫原并调节e。亚单位含量的疫苗。不含热亚基或有毒全毒素的大肠热肠毒素（LTB），其可用于诱导经粘膜管理的局部免疫原性对局部和全身的保护性反应

2. MUTANT GENE amp;Dgr; ENCODING POLYPEPTIDE ELICITING ACTIVITY OF HUMAN GAMMA-INTERFERON, RECOMBINANT PLASMID amp;Dgr; PROVIDING EXPRESSION OF amp;Dgr; GENE IN ESCHERICHIA COLI AND STRAIN ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE ELICITING ACTIVITY OF HUMAN GAMMA-INTERFERON [P] . 外国专利： RU2105813C1 . 1998-02-27

机译：突变基因编码人类γ-干扰素，重组质粒和多肽的多肽激活活性提供＆Dgr;大肠杆菌和应变大肠杆菌中的基因-人γ-干扰素多肽激活活性的生产者。

3. Mutant form of Escherichia coli heat-labile bacterial enterotoxin, composition and vaccine comprising thereof as well as use of this mutant form [P] . 外国专利： CZ298131B6 . 2007-07-04

机译：大肠杆菌热不稳定细菌肠毒素的突变形式，包含其的组合物和疫苗以及该突变形式的用途

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Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a LiveSalmonella enterica Serovar Typhimurium Vaccine Strain

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