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首页> 外文期刊>Infection and immunity >Ongoing Horizontal and Vertical Transmission of Virulence Genes and papA Alleles among Escherichia coliBlood Isolates from Patients with Diverse-Source Bacteremia
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Ongoing Horizontal and Vertical Transmission of Virulence Genes and papA Alleles among Escherichia coliBlood Isolates from Patients with Diverse-Source Bacteremia

机译：不同来源细菌血症患者的大肠杆菌分离株之间毒力基因和papA等位基因的水平和垂直传播

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The phylogenetic distributions of multiple putative virulence factors (VFs) and papA (P fimbrial structural subunit) alleles among 182 Escherichia coli blood isolates from patients with diverse-source bacteremia were defined. Phylogenetic correspondence among these strains, the E. coliReference (ECOR) collection, and other collections of extraintestinal pathogenic E. coli (ExPEC) was assessed. Although among the 182 bacteremia isolates phylogenetic group B2 predominated, exhibited the greatest concentration of individual VFs, and contained the largest number of familiar virulent clones, other phylogenetic groups exhibited greater concentrations of certain VFs than did group B2 and included several additional virulent clones. Certain of the newly detected VF genes, e.g., fyuA(yersiniabactin; 76%) and focG (F1C fimbriae; 25%), were as prevalent or more prevalent than their more familiar traditional counterparts, e.g., iut (aerobactin; 57%) and sfaS (S fimbriae; 14%), thus possibly offering additional useful targets for preventive interventions. Considerable diversity of VF profiles was observed at every level within the phylogenetic tree, including even within individual lineages. This suggested that many different pathways can lead to extraintestinal virulence in E. coli and that the evolution of ExPEC, which involves extensive horizontal transmission of VFs and continuous remodeling of pathogenicity-associated islands, is a highly active, ongoing process.
机译：定义了来自不同来源菌血症患者的182株大肠埃希菌血液分离物中多个推定毒力因子（VFs）和 papA （P纤维结构亚单位）等位基因的系统发育分布。这些菌株， E。大肠杆菌参考（ECOR）集合以及肠外致病性 E的其他集合。评估了大肠杆菌（ExPEC）。尽管在182个菌血症分离株中，系统发生组B2占主导地位，表现出最高的单个VF浓度，并且包含数量最多的熟悉的有毒克隆，但其他系统发生组显示的某些VF浓度比B2组更高，并且包括几个其他的有毒克隆。新检测到的某些VF基因，例如 fyuA （耶尔西菌素; 76％）和 focG （F1C菌毛; 25％），比它们的流行程度更高或更普遍。熟悉的传统对应物，例如 iut （aerobactin; 57％）和 sfaS （S菌毛; 14％），因此可能为预防干预措施提供了更多有用的目标。在系统发育树的每个水平上，甚至在单个谱系中，都观察到了相当多的VF分布图。这表明许多不同的途径可以导致 E的肠道外毒力。大肠埃希菌的进化，其中包括VF的广泛水平传播和与致病性相关的岛屿的连续重塑，是一个高度活跃的，持续的过程。

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