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首页> 外文期刊>Infection and immunity >Immunization with Pneumocystis carinii gpA Is Immunogenic but Not Protective in a Mouse Model of P. carinii Pneumonia
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Immunization with Pneumocystis carinii gpA Is Immunogenic but Not Protective in a Mouse Model of P. carinii Pneumonia

机译：卡氏肺孢子虫gpA的免疫是免疫原性，但在卡氏疟原虫肺炎的小鼠模型中没有保护作用。

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Immunization with whole Pneumocystis carinii has been shown to protect mice from the development of P. carinii pneumonia (PCP) when they are subsequently immunosuppressed and challenged with viable organisms. To determine whether these results could be duplicated by using a subunit vaccine, we examined the immunogenicity and efficacy of an immunization strategy based on P. carinii gpA. This antigen was chosen for study because passive immunoprophylaxis, based on gpA, has been shown to be partially protective in various animal models of infection. Immunization with gpA produced an anti-gpA specific antibody response comparable to that resulting from immunization with whole organisms. However, in contrast to immunization with whole P. carinii, which was protective, immunization with gpA did not protect T-cell-depleted mice from the development of PCP. These studies suggest that other antigens in addition to gpA need to be evaluated for their role in protective immunity against P. carinii.
机译：完整的卡氏肺孢子虫免疫已被证明可以保护小鼠免受 P的发展。卡林氏肺炎（PCP），随后对其进行免疫抑制并用活菌攻击。为了确定是否可以通过使用亚单位疫苗复制这些结果，我们研究了基于 P的免疫策略的免疫原性和功效。卡林氏菌选择该抗原进行研究是因为基于gpA的被动免疫预防已在多种感染动物模型中显示出部分保护作用。用gpA免疫产生的抗gpA特异性抗体反应与整个生物体免疫产生的反应相当。但是，与整个 P免疫相比。具有保护性的卡林氏菌（carinii）用gpA免疫不能保护T细胞耗尽的小鼠免于PCP的发展。这些研究表明，除了gpA外，还需要评估其他抗原在针对 P的保护性免疫中的作用。卡林氏。

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