Expression of Heat-Stable Enterotoxin STb by Adherent Escherichia coli Is Not Sufficient To Cause Severe Diarrhea in Neonatal Pigs

Thomas A. Casey; Cheryl J. Herring; Robert A. Schneider; Brad T. Bosworth; Shannon C. Whipp

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Expression of Heat-Stable Enterotoxin STb by Adherent Escherichia coli Is Not Sufficient To Cause Severe Diarrhea in Neonatal Pigs

机译：粘附大肠杆菌表达热稳定肠毒素STb不足以引起新生猪严重腹泻

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The role of Escherichia coli heat-stable enterotoxin B (STb) in neonatal porcine diarrhea caused by enterotoxigenic E. coli was examined by comparing adherent isogenic strains with or without STb. The cloned STb gene (in the plasmid pRAS1) was electroporated into a nonenterotoxigenic strain (226M) which expresses the F41 adhesin. Strain 226M pRAS1 adhered and expressed STb in vivo, causing fluid secretion in ligated ileal loops in neonatal pigs. Although strain 226M pRAS1 caused very mild diarrhea in some orally inoculated neonatal pigs, the weight loss in these pigs was similar to that caused by the parental strain without STb. We conclude that STb does not significantly contribute to diarrhea caused by enterotoxigenic E. coli in neonatal pigs.

机译：大肠埃希氏菌热稳定肠毒素B（STb）在产肠毒素 E所致的新生猪腹泻中的作用。通过比较带有或不带有STb的贴壁同基因菌株来检查大肠杆菌。将克隆的STb基因（在质粒pRAS1中）电穿孔到表达F41粘附素的非肠毒素菌株（226M）中。菌株226M pRAS1粘附并在体内表达STb，导致新生猪结扎回肠al中的液体分泌。尽管226M pRAS1菌株在一些经口接种的新生猪中引起了非常轻微的腹泻，但这些猪的体重减轻与无STb的亲本菌株引起的体重减轻相似。我们得出的结论是，STb不会显着促进由产肠毒素的 E引起的腹泻。猪中的大肠杆菌。 展开▼

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《Infection and immunity》 |1998年第3期|共3页

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Thomas A. Casey; Cheryl J. Herring; Robert A. Schneider; Brad T. Bosworth; Shannon C. Whipp;
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中图分类医学免疫学;

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1. Immunization of swine with heat-stable Escherichia coli enterotoxin coupled to a carrier protein does not protect suckling pigs against an Escherichia coli strain that produces heat-stable enterotoxin. [J] . H W Moon, A L Baetz, R A Giannella Infection and immunity . 1983,第2期

机译：用与载体蛋白偶联的热稳定大肠杆菌肠毒素对猪进行免疫，不能保护乳猪免受产生热稳定肠毒素的大肠杆菌菌株的侵害。

2. COMPARISON OF THE NUCLEOTIDE SEQUENCE OF ENTEROAGGREGATIVE ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN 1 GENES AMONG DIARRHEA-ASSOCIATED ESCHERICHIA COLI [J] . Yamamoto T., Sato F., Kato A., FEMS Microbiology Letters . 1997,第1期

机译：腹泻型肠埃希氏菌热稳定肠毒素1基因核苷酸序列的比较

3. An Outbreak of Diarrhea in Mandera, Kenya, due to Escherichia coli Serogroup O-Nontypable Strain That Had a Coding Gene for Enteroaggregative E-coli Heat-Stable Enterotoxin 1 [J] . Ochi Sadayuki, Shah Mohammad, Odoyo Erick, The American Journal of Tropical Medicine and Hygiene . 2017,第2期

机译：由于大肠杆菌的大肠杆菌血清群O-NONTYPABLE菌株爆发了纽姆拉，肯尼亚爆发，具有用于肠烧结e-Coli热稳定肠毒素1的编码基因

4. Evaluation of efficacy of Escherichia coli bacterin in controlling neonatal diarrhea in pigs (Scourmune ) under field condition [C] . G. Cunningham, L. Coulombe, R. Fleck, Annual Meeting of the American Association of Swine Veterinarians . 2005

机译：大肠杆菌菌株评价在田间条件下猪（浅滩）中新生儿腹泻控制新生儿腹泻的疗效

5. Significance of LT and STb enterotoxins in the virulence of F4+ Escherichia coli in pigs. [D] . Erume, Joseph. 2008

机译：LT和STb肠毒素在猪F4 +大肠杆菌毒力中的意义。

6. Note: Expression of Heat-Stable Enterotoxin STb by Adherent Escherichia coli Is Not Sufficient To Cause Severe Diarrhea in Neonatal Pigs [O] . Thomas A. Casey, Cheryl J. Herring, Robert A. Schneider, 1998

机译：注意：粘附大肠杆菌表达热稳定肠毒素STb不足以引起新生猪严重腹泻

7. Expression of Heat-Stable Enterotoxin STb by Adherent Escherichia coli Is Not Sufficient To Cause Severe Diarrhea in Neonatal Pigs [O] . Thomas A. Casey, Cheryl J. Herring, Robert A. Schneider, 1998

机译：粘附的大肠杆菌的热稳定肠毒素STB的表达不足以引起新生儿猪的严重腹泻

8. Enteroaggregative Escherichia coli Heat-Stable Enterotoxin 1 Represents AnotherSubfamily of E. coli Heat-Stable Toxin. (Reannouncement with New Availability Information) [R] . Savarino, S. J., Fasano, A., Watson, J., 1993

机译：肠聚集性大肠杆菌热稳定肠毒素1代表另一个大肠杆菌热稳定毒素家族。（重新公布新的可用性信息）

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3. Inhibition of diarrhea induced by escherichia coli heat-stable enterotoxin [P] . 外国专利： US4701458A . 1987-10-20

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机译：鉴定与大肠埃希氏菌相关的肠道疾病的猪的方法，分离与大肠埃希氏菌相关的肠道疾病的猪的方法，分离的DNA分子（变异体），分子分析以检测大肠埃希氏菌和小肠结肠菌大肠埃希氏菌F18受体

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Expression of Heat-Stable Enterotoxin STb by Adherent Escherichia coli Is Not Sufficient To Cause Severe Diarrhea in Neonatal Pigs

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