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Antibody Response to Cryptococcus neoformans Proteins in Rodents and Humans

机译：啮齿动物和人类对新型隐球菌蛋白的抗体反应

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The prevalence and specificity of serum antibodies toCryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcosis, in matched samples from HIV-positive individuals who did not develop cryptococcosis, and in HIV-negative individuals. Rodents had little or no serum antibody reactive with C. neoformans proteins prior to infection. The intensity and specificity of the rodent antibody response were dependent on the species, the mouse strain, and the viability of the inoculum. All humans had serum antibodies reactive with C. neoformans proteins regardless of the potential exposure, the HIV infection status, or the subsequent development of cryptococcosis. Our results indicate (i) a high prevalence of antibodies reactive with C. neoformansproteins in the sera of rodents after cryptococcal infection and in humans with or without HIV infection; (ii) qualitative and quantitative differences in the antibody profiles of HIV-positive individuals; and (iii) similarities and differences between humans, mice, and rats with respect to the specificity of the antibodies reactive with C. neoformans proteins. The results are consistent with the view that C. neoformans infections are common in human populations, and the results have implications for the development of vaccination strategies against cryptococcosis.
机译：在有或没有实验室可能暴露于 C病史的个体中，在患有实验性感染的小鼠和大鼠中研究了针对新隐球菌蛋白的血清抗体的普遍性和特异性。 neoformans ，人类发展成隐球菌的人类免疫缺陷病毒（HIV）阳性个体，未发展成隐球菌的HIV阳性个体和HIV阴性个体的配对样本。啮齿动物几乎没有血清抗体与 C反应。感染前的新甲虫蛋白。啮齿动物抗体反应的强度和特异性取决于物种，小鼠品系和接种物的生存力。所有人类的血清抗体都可与 C反应。新蛋蛋白，无论其潜在的接触，HIV感染状况或后来的隐球菌病发展。我们的结果表明（i）与 C有反应性的抗体普遍存在。隐球菌感染后的啮齿动物血清中以及患有或未感染HIV的人类血清中的新甲虫蛋白; （ii）HIV阳性个体抗体谱的定性和定量差异; （iii）人，小鼠和大鼠在与 C反应性抗体的特异性方面的异同。新甲虫蛋白。结果与 C视图一致。新甲虫感染在人类中很常见，其结果对制定针对隐球菌的疫苗接种策略具有重要意义。

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