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首页> 外文期刊>Infection and immunity >Heat-Shocked Monocytes Are Resistant toStaphylococcus aureus-Induced Apoptotic DNA Fragmentation due to Expression of HSP72
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Heat-Shocked Monocytes Are Resistant toStaphylococcus aureus-Induced Apoptotic DNA Fragmentation due to Expression of HSP72

机译：热休克的单核细胞对金黄色葡萄球菌诱导的凋亡DNA片段由于HSP72的表达具有抗性。

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Human peripheral blood monocytes became apoptotic following phagocytosis of Staphylococcus aureus. The consequences of heat stress for monocytes were studied with regard to the effect onS. aureus-induced apoptosis. Exposure of monocytes to 41.5°C for 1 h resulted in HSP72 expression and had no influence on phagocytosis of bacteria; moreover, phagocytosis of S. aureus immediately or shortly after heat shock had no effect on the S. aureus-induced monocyte apoptosis, as evidenced by DNA fragmentation assay. In contrast, cells which recovered from heat shock for 18 to 24 h, although active as phagocytes, were resistant to the S. aureus-induced apoptosis. The observed protective effect was related to the induction of HSP72, since blocking of HSP72 synthesis by an antisense oligomer abolished the protective effect of heat shock on bacterium-induced monocyte apoptosis.
机译：吞噬金黄色葡萄球菌后，人外周血单核细胞凋亡。就对em的影响研究了热应激对单核细胞的影响。金黄色葡萄球菌诱导的细胞凋亡将单核细胞暴露于41.5°C 1小时会导致HSP72表达，并且对细菌的吞噬作用没有影响。此外，吞噬 S。热休克后立即或短期内对金黄色葡萄球菌没有影响。 DNA片段分析证实金黄色葡萄球菌诱导单核细胞凋亡。相反，从热激中恢复18至24 h的细胞尽管具有吞噬细胞的活性，但对 S具有抗性。金黄色葡萄球菌诱导的细胞凋亡观察到的保护作用与HSP72的诱导有关，因为通过反义寡聚物阻断HSP72的合成消除了热激对细菌诱导的单核细胞凋亡的保护作用。

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