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首页> 外文期刊>Infection and immunity >Expanded Safety and Immunogenicity of a Bivalent, Oral, Attenuated Cholera Vaccine, CVD 103-HgR Plus CVD 111, in United States Military Personnel Stationed in Panama
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Expanded Safety and Immunogenicity of a Bivalent, Oral, Attenuated Cholera Vaccine, CVD 103-HgR Plus CVD 111, in United States Military Personnel Stationed in Panama

机译：在巴拿马驻扎的美国军事人员中增加了双价口服减毒霍乱疫苗CVD 103-HgR Plus CVD 111的安全性和免疫原性

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To provide optimum protection against classical and El Tor biotypes of Vibrio cholerae O1, a single-dose, oral cholera vaccine was developed by combining two live, attenuated vaccine strains, CVD 103-HgR (classical, Inaba) and CVD 111 (El Tor, Ogawa). The vaccines were formulated in a double-chamber sachet; one chamber contained lyophilized bacteria, and the other contained buffer. A total of 170 partially-immune American soldiers stationed in Panama received one of the following five formulations: (a) CVD 103-HgR at 108 CFU plus CVD 111 at 107 CFU, (b) CVD 103-HgR at 108CFU plus CVD 111 at 106 CFU, (c) CVD 103-HgR alone at 108 CFU, (d) CVD 111 alone at 107 CFU, or (e) inactivated Escherichia coli placebo. Among those who received CVD 111 at the high or low dose either alone or in combination with CVD 103-HgR, 8 of 103 had diarrhea, defined as three or more liquid stools. None of the 32 volunteers who received CVD 103-HgR alone or the 35 placebo recipients had diarrhea. CVD 111 was detected in the stools of 46% of the 103 volunteers who received it. About 65% of all persons who received CVD 103-HgR either alone or in combination had a fourfold rise in Inaba vibriocidal titers. The postvaccination geometric mean titers were comparable among groups, ranging from 450 to 550. Ogawa vibriocidal titers were about twice as high in persons who received CVD 111 as in those who received CVD 103-HgR alone (600 versus 300). The addition of CVD 111 improved the overall seroconversion rate and doubled the serum Ogawa vibriocidal titers, suggesting that the combination of an El Tor and a classical cholera strain is desirable. While CVD 111 was previously found to be well tolerated in semiimmune Peruvians, the adverse effects observed in this study indicate that this strain requires further attenuation before it can be safely used in nonimmune populations.
机译：为了对霍乱弧菌O1的经典和El Tor生物型提供最佳保护，通过结合两种减毒活疫苗株CVD 103-HgR（经典，Inaba）开发了单剂量口服霍乱疫苗CVD 111（小川县El Tor）。疫苗在双腔小袋中配制;一个小室包含冻干细菌，另一个小室包含缓冲液。派驻巴拿马的170名部分免疫的美国士兵接受以下五种配方之一：（a）10 8 CFU的CVD 103-HgR和10 7 CFU，（b）10 8 CFU处的CVD 103-HgR加上10 6 CFU处的CVD 111，（c）10 8处的CVD 103-HgR CFU，（d）10 7 CFU单独使用CVD 111或（e）灭活的大肠杆菌安慰剂。在那些单独或与CVD 103-HgR一起以高剂量或低剂量接受CVD 111的患者中，有103例中有8例腹泻，被定义为三个或更多的粪便。单独接受CVD 103-HgR的32名志愿者或35名安慰剂接受者均未出现腹泻。在接受该治疗的103位志愿者中，有46％的粪便中检测到CVD 111。单独或联合接受CVD 103-HgR的所有人中，约有65％的Inaba杀虫滴度提高了四倍。疫苗接种后的几何平均滴度在各组之间是可比的，范围从450到550。与接受单独的CVD 103-HgR的人相比，接受CVD 111的人的Ogawa杀螨滴度大约是其两倍（600对300）。 CVD 111的添加改善了总的血清转化率并使血清Ogawa杀弧菌滴度提高了一倍，这表明El Tor和经典霍乱菌株的组合是理想的。虽然先前发现CVD 111在半免疫秘鲁人中具有良好的耐受性，但在这项研究中观察到的不利影响表明，该菌株需要进一步减毒才能将其安全用于非免疫人群。

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