Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.

Y Suzuki; A Kobayashi

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Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.

机译：弓形虫感染小鼠中抗辐射和可塑性粘附的抑制细胞抑制未应答的T和B细胞的抗体反应。

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In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.

机译：在弓形虫感染的急性期，辅助T细胞和B细胞的功能在对二硝基苯酚（DNP）偶联的蛋白抗原的一抗反应中受到抑制。在感染过程中，对T细胞的抑制作用似乎比对B细胞的抑制作用持续更长的时间，因为对绵羊T细胞（一种T依赖性抗原）的抑制作用持续的时间比对DNP-Ficoll（一种T非依赖性抗原）的抑制作用持续的时间更长。。弓形虫感染和X射线照射（400 rads）小鼠脾脏中的塑料粘附细胞在体外对正常小鼠脾脏细胞的原代抗绵羊红细胞抗体反应具有较强的抑制活性。这些数据表明，抗辐射和粘附塑料的抑制细胞的激活引起弓形虫感染小鼠中T细胞和B细胞的抑制。

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《Infection and immunity》 |1983年第1期|共7页
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Y Suzuki; A Kobayashi;
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中图分类医学免疫学;
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1. Nonspecific suppression of primary antibody responses and presence of plastic-adherent suppressor cells in Toxoplasma gondii-infected mice. [J] . Y Suzuki, N Watanabe, A Kobayashi Infection and immunity . 1981,第1期

机译：刚地弓形虫感染小鼠中初级抗体应答的非特异性抑制和塑性粘附抑制细胞的存在。
2. Nonspecific suppression of initiation of memory cells in Toxoplasma gondii-infected mice. [J] . Y Suzuki, N Watanabe, A Kobayashi Infection and immunity . 1981,第1期

机译：弓形虫感染小鼠中记忆细胞启动的非特异性抑制。
3. Suppression of IgE antibody production in SJL mice. IV. Interaction of primed and unprimed T cells. [J] . T Itaya, Z Ovary The Journal of Experomental Medicine . 1979,第3期

机译：SJL小鼠中IgE抗体产生的抑制。 IV。启动和未启动的T细胞的相互作用。
4. Depleting Myeloid-derived Suppressor Cells with Janus Synthetic Nanoparticle Antibodies As A Cancer Immunotherapy [C] . Jiaying Liu, Pallab Pradhan, Randall Toy, Society for Biomaterials annual meeting and exposition . 2019

机译：用Janus合成纳米颗粒抗体耗尽骨髓来源的抑制细胞作为癌症免疫治疗。
5. ADAM10 is a critical regulator of B cell development, antibody production, and myeloid-derived suppressor cell expansion: Effects of B cell-specific ADAM10 deletion and overexpression in vivo. [D] . Gibb, David Randolph. 2012

机译：ADAM10是B细胞发育，抗体产生和髓样来源的抑制细胞扩增的关键调节剂：B细胞特异性ADAM10在体内的缺失和过表达的影响。
6. Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice. [O] . Y Suzuki, A Kobayashi 1983

机译：弓形虫感染小鼠中抗辐射和可塑性粘附的抑制细胞抑制未应答的T和B细胞的抗体反应。
7. Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice [O] . Y Suzuki, A Kobayashi 1983

机译：抑制在弓形虫咽喉杆菌的小鼠中抗体和塑性粘附抑制细胞抗体反应中未预期的T和B细胞
8. In vitro Antigen-Specific Antibody Response to the Species-Specific Surface Protein Antigens of Typhus Group Rickettsiae by Human Peripheral Blood Mononuclear Cells. Generation of an Antigen-Dependent Suppressor T Cell [R] . Misiti, J., Dasch, G. A. 1985

机译：体外抗原特异性抗体对人外周血单个核细胞对斑疹伤寒组立克次体的物种特异性表面蛋白抗原的反应。产生抗原依赖性抑制T细胞

Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.

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