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首页> 外文期刊>Infection and immunity >Rapid parasite multiplication rate, rather than immunosuppression, causes the death of mice infected with virulent Plasmodium yoelii.
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Rapid parasite multiplication rate, rather than immunosuppression, causes the death of mice infected with virulent Plasmodium yoelii.

机译：快速的寄生虫繁殖率，而不是免疫抑制作用，会导致感染了有毒的约氏疟原虫的小鼠死亡。

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摘要

Protective immunity against a lethal malaria challenge infection was passively transferred to naive recipient mice with spleen cells from donor mice bearing a lethal infection with the virulent YM strain of Plasmodium yoelii. Successful transfer of protection was contingent upon the elimination of residual, viable parasites from donor spleen cell suspensions prior to the infusion of cells. Passive transfer experiments failed to detect suppressor cells in the spleens of lethally infected mice because unfractionated spleen cells or T-cell-enriched spleen cells from mice infected with P. yoelii YM did not enhance parasitemias upon infusion into mice infected with cross-reactive nonvirulent P. yoelii 17X. We concluded that a form of protective immunity was generated during the course of virulent infection but that its expression was inconsequential because parasite growth apparently exceeded the capacity of the immune system to clear the infection.
机译：将针对致死性疟疾挑战感染的保护性免疫被动转移至幼稚的受体小鼠，该小鼠的脾细胞来自携带有致死性感染约氏疟原虫YM毒株的供体小鼠。保护的成功转移取决于在输注细胞之前从供体脾细胞悬浮液中消除残留的，可行的寄生虫。被动转移实验未能在致死性感染小鼠的脾脏中检测到抑制性细胞，因为来自感染约氏疟原虫YM的小鼠的未分离脾细胞或富含T细胞的脾细胞在注入交叉反应性非毒性P感染的小鼠中后并未增强寄生虫病。 yoelii 17X。我们得出的结论是，在强力感染过程中会产生某种形式的保护性免疫，但是其表达是无关紧要的，因为寄生虫的生长明显超过了免疫系统清除感染的能力。

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