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首页> 外文期刊>Infection and immunity >Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A.
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Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A.

机译：γ干扰素预防环孢菌素A治疗的小鼠单核细胞增生性李斯特菌致死性感染。

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摘要

The significance of interferons (IFNs) induced by Listeria monocytogenes in the antilisterial defense mechanism was studied in mice. Cyclosporin A (CsA) had no effect on IFN-alpha production that was induced in the bloodstream after intravenous infection of mice with L. monocytogenes, whereas IFN-gamma that was induced in the bloodstreams of control mice 6 h after stimulation with specific antigen in the late phase of infection was suppressed in CsA-treated mice, depending on the dose of the drug injected. The decrease in IFN-gamma production caused an increase in bacterial growth in the spleens and livers of CsA-treated mice. Furthermore, administration of a daily dose of CsA at 80 or 100 mg/kg of body weight resulted in fatal listeriosis, even though the dose was nonlethal for normal mice. The administration of recombinant murine IFN-gamma on day 0 of L. monocytogenes infection prevented CsA-treated mice from developing fatal listeriosis and restored their ability to produce IFN-gamma in the bloodstream, in response to specific antigen in the late phase of infection.
机译：在小鼠中研究了单核细胞增生性李斯特菌诱导的干扰素（IFN）在抗李斯特菌防御机制中的意义。环孢菌素A（CsA）对单核细胞增生李斯特氏菌小鼠静脉感染后在血流中诱导的IFN-α产生没有影响，而在对照小鼠的特定抗原刺激下6小时在血流中诱导的IFN-γ。在CsA处理的小鼠中，感染的晚期受到抑制，这取决于所注射药物的剂量。 IFN-γ产生的减少导致经CsA处理的小鼠的脾脏和肝脏细菌生长增加。此外，以每天80或100 mg / kg体重的剂量施用CsA会导致致命的李斯特菌病，即使该剂量对正常小鼠而言并非致命。在单核细胞增生李斯特氏菌感染的第0天给予重组鼠IFN-γ预防了CsA处理的小鼠发展致命性李斯特菌病，并恢复了它们在感染后期响应特定抗原而在血流中产生IFN-γ的能力。

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