Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens.

D A Rouse; S L Morris; A B Karpas; P G Probst; S D Chaparas

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Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens.

机译：抗鸟分枝杆菌复合蛋白抗原的单克隆抗体的生产，表征和物种特异性。

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The incidence of Mycobacterium avium-Mycobacterium intracellulare complex infections has increased in recent years primarily because a significant proportion of acquired immunodeficiency syndrome patients develop disseminated M. avium complex disease. In an effort to develop new tools to study these infections, we have produced eight monoclonal antibodies directed against M. avium. Western blot (immunoblot) specificity analysis and protease sensitivity assays indicate that four of these antibodies recognize M. avium-specific protein epitopes and two react with M. avium complex-specific peptide determinants. These monoclonal antibodies may be useful clinically in the diagnosis of M. avium complex disease and in the laboratory for isolation and characterization of native and recombinant M. avium complex antigens.

机译：近年来，鸟分枝杆菌-细胞内分枝杆菌复合物感染的发生率增加，这主要是因为很大一部分后天免疫机能丧失综合症患者发展为弥散性鸟分枝杆菌复合物疾病。为了开发新工具来研究这些感染，我们生产了八种针对鸟分枝杆菌的单克隆抗体。 Western印迹（免疫印迹）特异性分析和蛋白酶敏感性测定表明，这些抗体中有四种识别鸟鸟分枝杆菌特异性蛋白表位，另外两种与鸟鸟分枝杆菌复合物特异性肽决定簇反应。这些单克隆抗体在临床上可用于诊断鸟形支原体复合体疾病，并在实验室中用于分离和鉴定天然和重组鸟形支原体复合体抗原。

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《Infection and immunity》 |1990年第5期|共5页
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D A Rouse; S L Morris; A B Karpas; P G Probst; S D Chaparas;
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中图分类医学免疫学;
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1. Production and characterization of monoclonal antibodies against specific serotypes of Mycobacterium avium and the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex. [J] . A H Kolk, R Evers, D G Groothuis, Infection and immunity . 1989,第8期

机译：抗鸟分枝杆菌和鸟分枝杆菌-胞内分枝杆菌-s分枝杆菌复合物特定血清型的单克隆抗体的产生和表征。
2. Production and Characterization of Monoclonal Antibodies against a Major Membrane Protein of Mycobacterium avium subsp. paratuberculosis [J] . John P. Bannantine, Thomas J. Radosevich, Judith R. Stabel, Clinical and vaccine immunology: CVI . 2007,第3期

机译：针对鸟分枝杆菌亚种主要膜蛋白的单克隆抗体的生产和鉴定。副结核病
3. Production, characterization, and species specificity of five monoclonal antibodies to Mycobacterium tuberculosis. [J] . G V Kadival, S D Chaparas Journal of Clinical Microbiology . 1987,第1期

机译：五个针对结核分枝杆菌的单克隆抗体的生产，表征和物种特异性。
4. Production and characterization of monoclonal antibodies, aptamers and single chain antibodies to Mycobacterium avium subsp. paratuberculosis [C] . Bannantine JP, Sreevatsan S, Tizard ML, International Colloquium on Paratuberculosis . 2007

机译：单克隆抗体，适体和单链抗体对分枝杆菌的生产和表征。 paratuberculosis.
5. Production, characterization and possible applications of monoclonal antibodies generated against toluene diisocyanate-conjugated proteins. [D] . Ruwona, Tinashe Blessing. 2010

机译：抗甲苯二异氰酸酯偶联蛋白的单克隆抗体的生产，表征和可能的应用。
6. Production characterization and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens. [O] . D A Rouse, S L Morris, A B Karpas, 1990

机译：抗鸟分枝杆菌复合蛋白抗原的单克隆抗体的生产表征和物种特异性。
7. Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens [O] . D A Rouse, S L Morris, A B Karpas, 1990

机译：单克隆抗体对分枝杆菌抗植物蛋白抗原的生产，表征和物种特异性

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Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens.

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