• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >New mouse models for chronic Cryptosporidium infection in immunodeficient hosts.
【24h】

New mouse models for chronic Cryptosporidium infection in immunodeficient hosts.

机译：免疫缺陷宿主中慢性隐孢子虫感染的新小鼠模型。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cryptosporidium sp. causes fulminant diarrhea and chronic infection in immunocompromised, particularly human immunodeficiency virus-infected, persons. The lack of in vitro cultivation and a suitable animal model has limited development of effective treatment. We describe two new mouse models of chronic symptomatic cryptosporidiosis in adult athymic mice and in T-cell subset-depleted mice. A progressive infection, fatal within 4 months, occurred in most adult athymic mice; a few developed stable infections. Symptoms included dehydration, weight loss, intermittent diarrhea, and jaundice. Pathologic abnormalities and organisms localized in the intestine in stable infections but involved the hepatobiliary tree and pancreas in others. Lymphoid cells from histocompatible, Cryptosporidium sp.-immune mice cured infected nude mice. Identical infections occurred in neonatally infected BALB/c mice treated with anti-CD4 monoclonal antibodies alone or also with anti-CD8 monoclonal antibodies; the mice were cured when the monoclonal antibody treatments were stopped. These models will be useful in definition of the immune defects that permit chronic cryptosporidiosis to develop and in assessment of treatment modalities.
机译：隐孢子虫导致免疫力低下的人暴发性腹泻和慢性感染，特别是感染了人类免疫缺陷病毒的人。缺乏体外培养和合适的动物模型限制了有效治疗的发展。我们描述了在成人无胸腺小鼠和T细胞亚群耗竭的小鼠中慢性症状隐孢子虫病的两种新的小鼠模型。大多数成年无胸腺小鼠发生进行性感染，在4个月内致命。少数发展为稳定的感染。症状包括脱水，体重减轻，间歇性腹泻和黄疸。病理异常和生物位于肠道中，处于稳定的感染中，但涉及其他地方的肝胆树和胰腺。来自组织相容性隐孢子虫免疫小鼠的淋巴细胞治愈了感染的裸鼠。在单独用抗CD4单克隆抗体或也用抗CD8单克隆抗体治疗的新生儿感染的BALB / c小鼠中发生了相同的感染。停止单克隆抗体治疗后，小鼠治愈。这些模型将有助于定义允许慢性隐孢子虫病发展的免疫缺陷，并有助于评估治疗方式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号