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Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection

机译:白细胞介素18在宿主抗传播白色念珠菌感染中的作用

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摘要

In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-γ)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-γ.
机译:在静脉注射白色念珠菌的小鼠中,抗白介素18(IL-18)抗体的使用增加了肾脏中酵母的负荷。用抗IL-18抗体治疗γ-干扰素(IFN-γ)缺陷的小鼠对 Candida 的器官负荷没有影响,这表明IL-18的保护作用是通过内源性IFN-γ。

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