Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis

Flavia De Bernardis; Maria Boccanera; Daniela Adriani; Antonietta Girolamo; Antonio Cassone

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Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis

机译：阴道内和鼻内免疫同样有效地诱导阴道抗体并赋予针对阴道念珠菌病的保护

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Oophorectomized, estrogen-treated rats were immunized by the intravaginal or intranasal route with a mannoprotein extract (MP) or secreted aspartyl proteinases (Sap) of Candida albicans, with or without cholera toxin as a mucosal adjuvant. Both routes of immunization were equally effective in (i) inducing anti-MP and anti-Sap vaginal antibodies and (ii) conferring a high degree of protection against the vaginal infection by the fungus. These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route.

机译：经阴道切开或经鼻内途径用 Candida albicans 的甘露糖蛋白提取物（MP）或分泌的天冬氨酰蛋白酶（Sap）免疫经卵巢切除或经雌激素处理的大鼠，有或没有霍乱毒素作为粘膜佐剂。两种免疫途径在（i）诱导抗MP和抗Sap阴道抗体方面和（ii）对真菌的阴道感染具有高度保护作用方面均具有同等效力。这些数据表明适当的真菌抗原和佐剂可通过任一途径用于预防念珠菌性阴道炎。 展开▼

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《Infection and immunity》 |2002年第5期|共5页

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Flavia De Bernardis; Maria Boccanera; Daniela Adriani; Antonietta Girolamo; Antonio Cassone;
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中图分类医学免疫学;

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专利

1. Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques. [J] . Miyake A, Akagi T, Enose Y, Journal of Medical Virology . 2004,第3期

机译：通过灭活猕猴中灭活的SHIV捕获纳米球进行鼻内免疫诱导HIV特异性抗体反应并防止阴道SHIV传播。

2. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. [J] . Dubie RA, Maksaereekul S, Shacklett BL, Virology . 2009,第1期

机译：与IL-15的共免疫可增强由vif缺失的猿猴免疫缺陷病毒原病毒DNA疫苗诱导的细胞免疫应答，并提供针对SIVmac251的阴道攻击的部分保护。

3. Peptide immunization of guinea pigs against Chlamydia psittaci (GPIC agent) infection induces good vaginal secretion antibody response, in vitro neutralization and partial protection against live challenge. [J] . Volp K, Mathews S, Timms P, Immunology and Cell Biology . 2001,第3期

机译：豚鼠针对鹦鹉热衣原体（GPIC试剂）感染的肽免疫可诱导良好的阴道分泌抗体反应，体外中和作用以及对活病毒的部分保护。

4. Intranasal immunization with codon optimized MOMP DNA vaccine confers protection against Chlamydia trachomatis infection [C] . Yan Zheng, Wei-Ming Zhao, Hong Wang, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：经密码子优化的MOMP DNA疫苗进行鼻内免疫可预防沙眼衣原体感染

5. Effects of diabetes on vaginal physiology: Amelioration of diabetes-induced vaginal structural and functional changes by estradiol [D] . Cushman, Tulay Tankir 2009

机译：糖尿病对阴道生理的影响：雌二醇改善糖尿病引起的阴道结构和功能改变

6. Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis [O] . Flavia De Bernardis, Maria Boccanera, Daniela Adriani, 2002

机译：阴道内和鼻内免疫同样有效地诱导阴道抗体并赋予针对阴道念珠菌病的保护

7. Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis [O] . De Bernardis, Flavia, Boccanera, Maria, Adriani, Daniela, 2002

机译：阴道内和鼻内免疫同样有效地诱导阴道抗体并赋予针对阴道念珠菌病的保护

1. 042猴免疫缺陷病毒阴道内接种后可快速感染宫颈阴道上层内树突细胞 [J] . . 微生物与感染 . 2001,第004期

2. 应用克林霉素和甲硝唑阴道给药治疗细菌性阴道病对阴道内乳酸杆菌的影响 [J] . Nyirjesy ,P. ,Mclntosh . 世界核心医学期刊文摘：妇产科学分册 . 2006,第009期

3. 用酶标抗体免疫组化法测定性交后阴道内容物中精了的ABO血型 [J] . 欧炯文 ,李英碧 ,等 . 中国法医学杂志 . 1993,第001期

4. 米索前列醇阴道内给药诱导流产的临床观察 [J] . 廖慧萍 . 家庭医药 . 2020,第008期

5. 阴道内给米索前列醇诱导流产的探索 [J] . 黄紫蓉 ,杜明昆 . 中国计划生育学杂志 . 1996,第005期

6. UPOINT因子对CP/CPPS患者阴道内射精潜伏时间的影响 [C] . 程易 ,戴宁 ,陈乔 . 世界中联男科专业委员会第八届学术年会、国际中医男科第十届学术大会、海峡两岸中医男科第五届学术论坛 . 2016

7. 自制中药洗剂对外阴阴道假丝酵母菌病患者阴道内致病菌及正常菌抑制情况的研究 [A] . 祝秀芝 . 2010

1. 阴道内射精潜伏期及阴道阵挛监测装置 [P] . 中国专利： CN110833392A . 2020-02-25

2. 一种能避免阴道内乳杆菌被杀灭的治疗阴道炎的药剂 [P] . 中国专利： CN105727021B . 2019.09.10

3. The composition of a vaginal gel containing drug combination for the treatment of vaginal candidiasis caused by strains sensitive and resistant to fluconazole [P] . 外国专利： BR102017004928A2 . 2018-10-30

机译：包含药物组合物的阴道凝胶的组合物，用于治疗由对氟康唑敏感和耐药的菌株引起的阴道念珠菌病

4. intravaginal release system for controlled release of therapeutically active substances or prodrugs thereof and method for providing or feeding protection to a mammalian female against vaginal bacterial and fungal infection or enhancing protection against sexually transmitted diseases [P] . 外国专利： BRPI0815936A2 . 2019-08-27

机译：用于控制释放治疗活性物质或其前药的阴道内释放系统，以及向哺乳动物提供或提供对阴道细菌和真菌感染的防护或增强对性传播疾病的防护的方法

5. Intravaginal Rings and Vaginal Ring whole body, and Method for preparing and using the Vaginal Ring. [P] . 外国专利： AR011427A1 . 2000-08-16

机译：阴道环和阴道环的整体，以及制备和使用阴道环的方法。

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Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis

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